The Effect of Degree of Rice-polishing on Glycaemic Response

Not Applicable

Completed

• Conditions: Diabetes Mellitus; Obesity

• Registration Number: NCT04228341
• Lead Sponsor: Clinical Nutrition Research Centre, Singapore

Brief Summary

To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

Detailed Description

There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Study Timeline

• Study Start: 2019-02-13
• Primary Completion: 2019-07-26
• Study First Submitted: 2020-01-11
• Study First Submitted QC: 2020-01-11
• Study First Posted: 2020-01-14
• Study Completion: 2020-06-18
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-19
• Last Update Posted: 2021-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 14

Inclusion Criteria

• Male
• Chinese ethnicity
• Age ≥21 and ≤ 60 years
• Body mass index between 18.5 to 25 kg/m2
• Normal blood pressure =<140/90 mmHg
• Fasting blood glucose <6.0 mmol/L
• In general good health

Exclusion Criteria

• Current smoker
• Have any metabolic diseases (such as diabetes, hypertension etc)
• Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• Have intolerances or allergies to any foods
• Currently partake in sports at the competitive and/or endurance levels
• Intentionally restrict food intake

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Glucose	Up to 180 minutes	Whole capillary blood glucose will be measure using Hemocue analyser

Secondary Outcome Measures

Name	Time	Method
Insulin	Up to 180 minutes	Capillary plasma will be measure using Cobas analyser

Trial Locations

Locations (1)

Clinical Nutrition Research Centre; 🇸🇬 Singapore, Singapore