Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- Rhode Island Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Generalized Self-Efficacy Scale
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Modifying health behaviors like physical activity level, diet, stress, and mental activity level can lower risk for Alzheimer's disease, but many middle-aged and older adults find it difficult to sustain health behavior changes over the long term. This project will develop a new intervention that educates people about Alzheimer's disease risk factors and helps them understand how their personal health beliefs may prevent them from making long-lasting lifestyle changes. The goal is to help people sustain health behavior changes to prevent or delay the onset of Alzheimer's disease and related dementias.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age 45-69 years
- •normal cognition (Minnesota Cognitive Acuity Scale \> 52)
- •English language fluency
- •at least two of the following: i) BMI \> 24.9; ii) systolic blood pressure \> 125 mmHg; iii) LDL cholesterol \> 115 mg/dL; iv) HbA1C \> 6.0%; v) at least one APOE ε4 allele; vi) first-degree relative with AD.
Exclusion Criteria
- •history of serious mental illness (i.e., schizophrenia, bipolar disorder)
- •history of neurologic or neurodevelopmental disorder
- •current alcohol or drug use disorder based on self-report
- •current enrollment in an AD prevention clinical trial.
Outcomes
Primary Outcomes
Generalized Self-Efficacy Scale
Time Frame: 12 weeks
10-item self-report questionnaire assessing belief in one's own abilities; higher scores indicate greater self-efficacy
Perceived Threat of Alzheimer's Disease Scale
Time Frame: 12 weeks (treatment endpoint)
7-item Likert-type scale assessing perceived likelihood, concern, and consequences of Alzheimer's disease; higher scores indicate greater perceived threat
Dementia Awareness Questionnaire
Time Frame: 12 weeks
self-report measure of knowledge of modifiable Alzheimer's disease risk factors; higher scores are associated with greater dementia awareness
Secondary Outcomes
- Florida Cognitive Activities Scale(12 weeks)
- Mediterranean Diet Assessment Tool(12 weeks)
- CHAMPS Activities Questionnaire for Older Adults(12 weeks)
- Perceived Stress Scale(12 weeks)
- Positive and Negative Affect Schedule(12 weeks)