Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Generalized Self-Efficacy Scale
研究概览
简要总结
Modifying health behaviors like physical activity level, diet, stress, and mental activity level can lower risk for Alzheimer's disease, but many middle-aged and older adults find it difficult to sustain health behavior changes over the long term. This project will develop a new intervention that educates people about Alzheimer's disease risk factors and helps them understand how their personal health beliefs may prevent them from making long-lasting lifestyle changes. The goal is to help people sustain health behavior changes to prevent or delay the onset of Alzheimer's disease and related dementias.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 45-69 years
- •normal cognition (Minnesota Cognitive Acuity Scale > 52)
- •English language fluency
- •at least two of the following: i) BMI > 24.9; ii) systolic blood pressure > 125 mmHg; iii) LDL cholesterol > 115 mg/dL; iv) HbA1C > 6.0%; v) at least one APOE ε4 allele; vi) first-degree relative with AD.
排除标准
- •history of serious mental illness (i.e., schizophrenia, bipolar disorder)
- •history of neurologic or neurodevelopmental disorder
- •current alcohol or drug use disorder based on self-report
- •current enrollment in an AD prevention clinical trial.
结局指标
主要结局
Generalized Self-Efficacy Scale
时间窗: 12 weeks
10-item self-report questionnaire assessing belief in one's own abilities; higher scores indicate greater self-efficacy
Perceived Threat of Alzheimer's Disease Scale
时间窗: 12 weeks (treatment endpoint)
7-item Likert-type scale assessing perceived likelihood, concern, and consequences of Alzheimer's disease; higher scores indicate greater perceived threat
Dementia Awareness Questionnaire
时间窗: 12 weeks
self-report measure of knowledge of modifiable Alzheimer's disease risk factors; higher scores are associated with greater dementia awareness
次要结局
- Florida Cognitive Activities Scale(12 weeks)
- Mediterranean Diet Assessment Tool(12 weeks)
- CHAMPS Activities Questionnaire for Older Adults(12 weeks)
- Perceived Stress Scale(12 weeks)
- Positive and Negative Affect Schedule(12 weeks)