Basic Auditory Processing and Acoustico-verbal Hallucinations: a Pathophysiological Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Schizophrenia
- Sponsor
- Hôpital le Vinatier
- Enrollment
- 59
- Locations
- 1
- Primary Endpoint
- percentage error in discrimination test psychoacoustic Tone Matching Task
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population worldwide. Although pathophysiology of this disease remains unclear, a growing interest is emerging for low-level sensory function, acknowledging that deficits in early stages of sensory processing are related to higher-order cognitive disturbances in schizophrenia. In the field of auditory processing, symptoms as auditory-hallucinations were found correlated with disabilities to discriminate psychoacoustic parameters of sounds.
Detailed Description
Outcomes: Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test. The main objective is to assess this correlation. Our other objectives are to assess correlation between AHRS as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities. Impact of therapeutic procedures (neuromodulation, psychotherapy) conducted independently of our study on these psychoacoustic tests will also be assessed. Methods: 30 subjects with schizophrenia will be included. Clinical and psychoacoustic measures will be carried out at J-0. In the case of patients receiving therapeutic procedures independently of our study, new clinical and psychoacoustic measures will be carried out at J+7 and J+30.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age from 18 to 65 years old
- •Meeting DSM-5.0 criteria for schizophrenia
- •Auditory Hallucinations Rating Scale ≥ 8
- •Negative βHCG level if woman
- •Effective contraception if woman
- •Consent to be included in the study
Exclusion Criteria
- •Hearing impairment
- •Neurologic disorder
- •Other psychiatric disorder from the DSM-5.0 section II
- •Developed musical abilities (regular practice of singing or a musical instrument)
- •Pregnancy
- •Does not consent to be included in the study
- •Lacking in legal capacity
Outcomes
Primary Outcomes
percentage error in discrimination test psychoacoustic Tone Matching Task
Time Frame: immediately after treatment
Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test.
Secondary Outcomes
- Score the item hallucinations of psychometric ( positive and negative syndrome ) scale(immediately after treatment)