Coronary artery bypass graft (CABG) off- or on-pump revascularisation study

Population Health Research Institute (PHRI) (Canada)0 个研究点目标入组 4,700 人开始时间: 2008年2月4日最近更新: 2019年4月29日

适应症

试验速览

•1. Require isolated CABG with median sternotomy
•2. Provide written informed consent
•3. 21 years of age and older, either sex
•4. Have one risk factor or more:
•4.1. Greater than or equal to 70 years age
•4.2. Peripheral vascular disease (previous peripheral bypass or amputation or ankle brachial index [ABI] less than 0.80)
•4.3. Cerebrovascular disease (history of stroke, transient ischaemic attack [TIA], carotid stenosis greater than 70%)
•4.4. Renal insufficiency (creatinine above upper limit of normal)
•4.5. Greater than 60 years of age with one of the following:
•4.5.1. Diabetes (oral hypoglycaemic agent and/or insulin)
•4.5.2. Urgent revascularisation (waiting in hospital)
•4.5.3. Left ventricular ejection fraction less than 35%
•4.5.4. Current or recent smokers (within 1 year of randomisation)

•1. Concomitant cardiac procedure associated with CABG
•2. Contra-indications to off-pump CABG or on-pump CABG (calcified aorta, intramuscular left anterior descending [LAD], calcified coronaries, small target vessels)
•3. Concomitant life-threatening disease likely to limit life expectancy to less than 2 years
•4. Prior enrolment in this trial
•5. Emergency CABG surgery (immediate revascularisation for haemodynamic instability)
•6. Redo CABG

发起方

Population Health Research Institute (PHRI) (Canada)