Pituitary hormone profile after Brain Injury
- Conditions
- Health Condition 1: S069- Unspecified intracranial injury
- Registration Number
- CTRI/2022/07/044009
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
1. Age 3 month to 16 years
2. Hospitalized for a clinical indication like altered sensorium, seizures, amnesia, repeated vomiting, bleeding nose or Ear, skull fracture, or neurological signs after traumatic brain injury
1. Patients who succumb within first 48 hours of hospitalization
2. Patients with pre-existing endocrinal disorder unrelated to existing illness
3. Patients with previously diagnosed static or progressive central nervous system disease (like epilepsy, brain tumor, meningoencephalitis, cerebral palsy)
4. Patients with history of consumption of drugs in the last 12 months which can affect interpretation of pituitary hormone levels (example corticosteroids, anti-epileptic drugs)
5. Patients with any major congenital anomalies (example neural tube defects) or chromosomal disorders
6. Patients who discontinue treatment before discharge
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of pituitary disorders in children with traumatic brain injuryTimepoint: Baseline, 6 months, 12 months, 24 months
- Secondary Outcome Measures
Name Time Method a.Association of pituitary dysfunction with the injury characteristics (severity, type, mechanism) <br/ ><br>b.Association of pituitary dysfunction with neuronal injury biomarkers <br/ ><br>c.Resolution of pituitary dysfunction in diagnosed cases during the study period <br/ ><br>Timepoint: 6, 12 and 24 months