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临床试验/NCT07337889
NCT07337889招募中不适用

Conceptualizing Borderline Personality Disorder as a Relationship Use Disorder

University Hospital, Montpellier1 个研究点 分布在 1 个国家目标入组 194 人开始时间: 2026年6月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
194
试验地点
1
主要终点
Relational Addiction

研究概览

简要总结

This study aims to explore a novel conceptualization of Borderline Personality Disorder (BPD) as a "Relationship Use Disorder." The research proposes that BPD shares key features with behavioral addictions, specifically addiction to interpersonal relationships. The study builds upon previous findings suggesting that individuals with BPD experience intense emotional dysregulation, including negative self-perception, shame, and a compulsive need for external validation. This addiction to relationships, much like substance use disorders, is thought to contribute significantly to the difficulties faced by these individuals, including interpersonal conflicts, self-destructive behaviors, and emotional instability.

The study seeks to demonstrate that the relational difficulties central to BPD meet the diagnostic criteria for addiction as defined by the DSM-5. It will also explore how these relational struggles are mediated by dysfunctional self-perception and whether they are linked to behaviors such as compulsive sexual behaviors (CSBD) or suicidal tendencies. Additionally, the research will investigate the relationship between addiction to relationships and neurobiological factors, including endorphin levels, in individuals with BPD compared to those with bipolar disorder and healthy controls. The hypothesis is that individuals with BPD will exhibit higher levels of relationship addiction, with this addiction being tied to their perception of self-worth and emotional experiences in relationships.

This innovative approach aims to refine the understanding of BPD, reduce stigma, and improve treatment strategies by providing scientific evidence supporting the conceptualization of BPD as a "Relationship Use Disorder."

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • General : aged 18-45
  • Specific :
  • Borderline personality disorder (BPD)assessed by SCID, without bipolar disorder
  • Bipolar disorder (assessed by SCID), without BPD (evaluated by SCID)
  • Healthy controls with no psychiatric disorders (screened by SCID).

排除标准

  • Psychotic disorders (evaluated by SCID)
  • lack of informed consent
  • Not affiliated with social security
  • Under judicial or administrative confinement or involuntary hospitalization
  • Protected by law (e.g., under guardianship)
  • Pregnancy or breastfeeding
  • Inability to understand, speak, or write in French
  • Inability to understand the study's purpose or methodology
  • Excluded from another study during the exclusion period
  • Participants who have received over €6000 in annual indemnities
  • For Bipolar Participants (without BPD) : Current moderate or severe depressive episode (BDI score > 18) or Current hypomanic/manic episode (YMRS < 12)

研究组 & 干预措施

Patients with borderline personality

Experimental

Patients with borderline personality disorder without bipolar disorder

干预措施: Relationship-use questionnaire (Other)

Patients with bipolar disorder

Experimental

patients with bipolar disorder without borderline personality disorder

干预措施: Relationship-use questionnaire (Other)

Healthy controls

Experimental

Healthy controls (i.e. without psychiatric disorders), from the general population

干预措施: Relationship-use questionnaire (Other)

结局指标

主要结局

Relational Addiction

时间窗: Measured at baseline

Using the experimental relationship-use questionnaire based on the DSM-5 Substance Use Disorder items among patients with Borderline Personality Disorder (BPD) without Bipolar Disorder (BD), those with BD without BPD, and healthy controls.

次要结局

  • Function Acquisition Speed Test (FAST)(Measured at baseline)
  • Visual Analogue Scale (VAS) for Perceived Alignment with BPD(Measured at baseline)
  • Love Addiction Inventory (LAI)(Measured at baseline)
  • Beta-Endorphin Levels(Measured at baseline)
  • Dysfunctional Self-Perception and Related Indicators (SES)(Measured at baseline)
  • Dysfunctional Self-Perception and Related Indicators (RSES)(Measured at baseline)
  • Dysfunctional Self-Perception and Related Indicators (ESS)(Measured at baseline)
  • Dysfunctional Self-Perception and Related Indicators (VAS)(Measured at baseline)
  • Painful Experiences Related to the Relational Object (MSR)(Measured at baseline)
  • Painful Experiences Related to the Relational Object (ESUL)(Measured at baseline)
  • Painful Experiences Related to the Relational Object (RSQ)(Measured at baseline)
  • Compulsive Sexual Behavior Disorder(Measured at baseline)
  • Non-Relational Addictive Propensity(Measured at baseline)
  • Suicidal Tendencies(Measured at baseline)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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