To Study the effect of olanzapine and amisulpride in post operative nausea and vomiting in laparoscopic gynecological surgeries -A randomized double-blind study

1.This prospective randomized double blinded comparative study will be conducted at our

institution over a period of 1.5 years.

2.In this study 110 ASA grade I and II patients between age 20 to 50 years posted for elective

laparoscopic gynecological surgeries requiring general anesthesia will be included.

3.After taking written informed consent, patients will be randomized into two groups (n= 110)by

computer generated random number table.

4.All patients will be thoroughly examined pre- operatively which includes history, general

physical examination, and checking the vital parameters, and systemic examination and ASA

grading of patients.

5.All the patients will be kept empty stomach for at least 6 hours before the procedure.

6.All the routine monitors will be attached and the preoperative baseline parameters (noninvasive

blood pressure, (NIBP), pulse rate (PR), and saturation (SPO2) )will be noted.An 18-Gauge IV

cannula will be secured all patients irrespective of the group they belong to.

7.Patients in group A will receive Inj amisulpride 5 mg slow iv 30 mins before induction .

Patients in group B will receive T.olanzapine 10mg P/O 90 mins before induction.

8.Patients will be given following premedication drugs, Inj glycopyrrolate 0.2mg iv ,Inj

Midazolam 1mg iv, Inj fentanyl(2mcg/kg) and induced with Inj propofol(1.5mg/kg) iv and Inj

vecuronium (0.1mg/kg) iv as muscle relaxant initially and followed by 0.02mg as maintenance.

9.At the end of Surgery patients will be extubated and monitored for postoperative nausea and

vomiting from ‘0’ hours .

10.Initial 2 hours: Monitoring every 30 minutes ,Then 2hrs,4hrs,6hrs,8hrs,12hrs,18hrs,24hrs.

11.Rescue antiemetic Inj dexamethasone 8 mg will be given if a patient develops postoperative

nausea and vomiting irrespective of the drug given.