Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Adherence to Penicillin Secondary Prophylaxis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 主要终点
- Cardiac function including vulvar involvement
研究概览
简要总结
According to American Heart Association criteria, patients who have had Rheumatic Fever (RF) should be treated with antibiotic prophylaxis. Continuous prophylaxis is recommended in patients with well-documented histories of RF and in those with evidence of rheumatic heart disease.
There is a limited data regarding adherence of patients to treatment and efficacy of treatment.
In this study, patients with RF who are older than 21 years will be collected from a computerized database of 'Maccabi Healthcare Services', one of the biggest Israeli Health Funds. Patients will be assigned to the study after obtaining informed consent.
Previous adherence to antibiotic prophylaxis will be examined according to computerized database of drugs which were issued to the patient since RF diagnosis.
Past history of cardiac involvement, including past Echocardiograms, will be collected from computerized database. In addition, the current cardiac state will be assessed by an experienced cardiologist, including a full new Echocardiogram examination.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 21 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 21 years who were diagnosed with RF (before age 18 years) according to the computerized database.
排除标准
- •patients with other rheumatic disease diagnosed before RF diagnosis
- •patients with other cardiac disease diagnosed before RF diagnosis
- •patients with neoplastic disease diagnosed before RF diagnosis
结局指标
主要结局
Cardiac function including vulvar involvement
时间窗: 60 days
Cardiac morphology and function measured by echocardiography
次要结局
未报告次要终点
研究者
Dr. Amir Ben-Tov
Medical Director online centers
Assuta Hospital Systems