ipbiopsie bij Sjogrens Syndrome.
- Conditions
- Sjogrens Syndroomauto-immuun aandoeningenXerostomie
- Registration Number
- NL-OMON22127
- Lead Sponsor
- Academisch Medisch Centrum, div. Immunology and Rheumatology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Patients undergoing lower lip biopsies for diagnostic purposes.
Exclusion Criteria
N/A
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Obtained material will be used to elucidate primarily the B-cell pathogenesis of Sjogren's Syndrome. Using immunohistochemistry, RNS and protein analysis, the B-cel receptor (BCR), T-cell receptor (TCR), a B-cell stimulating cytokine (APRIL) and the interaction between different immune cell populations and cytokines will be studied
- Secondary Outcome Measures
Name Time Method