ISRCTN78775328已完成不适用

Feasibility study using repeated intensive chemotherapy courses for patients with primary acute lymphoblastic leukemia in adults age 18 - 39 years inclusive: A phase II multicentre study

Dutch Haemato-Oncology Association (Stichting Hemato-Oncologie Volwassenen Nederland) (HOVON) (Netherlands)0 个研究点目标入组 50 人开始时间: 2010年9月6日最近更新: 2015年1月13日

研究概览

简要总结

暂无简介。

研究设计

研究类型: Interventional

入排标准

性别: All

入选标准

•1. Age 18 - 39 years inclusive
•2. Primary previously untreated ALL (including Philadelphia chromosome or BCR-ABL positive ALL)
•3. WHO performance status 0, 1, or 2
•4. Negative pregnancy test at inclusion if applicable
•5. Written informed consent

排除标准

•1. Mature B-cell ALL
•2. Acute undifferentiated leukemia
•3. Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease)
•4. Severe pulmonary dysfunction (CTCAE grade III-IV)
•5. Severe neurological or psychiatric disease
•6. Significant hepatic dysfunction (serum bilirubin or transaminases = 3 times normal level)
•7. Significant renal dysfunction (serum creatinine = 3 times normal level)
•8. History of active malignancy during the past 5 years with the exception of basal carcinoma of the skin or stage 0 cervical carcinoma
•9. Active, uncontrolled infections
•10. Patient known to be HIV-positive
•11. Patient is a lactating woman
•12. Any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol and follow-up schedule

研究者

发起方

Dutch Haemato-Oncology Association (Stichting Hemato-Oncologie Volwassenen Nederland) (HOVON) (Netherlands)

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