Transcranial Magnetic Stimulation combined with electromyography and electroencephalography as a diagnostic and prognostic tool in Juvenile Myoclonus Epilepsy.

Completed

• Conditions: Epilepsy; Seizures; 10039911

• Registration Number: NL-OMON41514
• Lead Sponsor: Stichting Epilepsie Instellingen Nederland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 122

Inclusion Criteria

In generally good health
Normal cognitive functioning
Speaking Dutch, English, French, German
1st epileptic seizure OR >2 years seizure free
Diagnosis of JME confirmed
12 years or older;for migraine:
18 years or older
Migraine with aura (3/10 attacks) diagnosed according to ICHD-III criteria
One or more attacks per year
<8 attacks per month or <15 headache days per month (chronic migraine)
At least 1 attack in the year prior to the investigation.
The measurement will take place in the interictal phase, so a participant should not have had an attack 3 days prior or 3 days after the measurement.

Exclusion Criteria

Use of medication with known effect on ion channel function (i.e. b-blocker)
Previous head/skull surgery (ferromagnetic material)
Diabetes mellitus (affects peripheral nervous system)
pregnancy (alters cortical excitability)
Neurological condition other than JME
Treated with anti-epileptic drugs before
Any neurological condition (including migraine)
Any psychiatric condition
1st degree family members with epilepsy;for migraine:
Use of prophylactic medication up to 4 weeks prior to measurement
Use of attack medication less than 3 days prior to the measurement
Headache on the day of measurement

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Study parameters: change in conventional cortical excitability parameters<br /><br>(motor threshold, MEP (motor evoked potential) amplitude, cortical silent<br /><br>period, recovery curve, short and long intra-cortical inhibition,<br /><br>intra-cortical facilitation).<br /><br><br /><br>Endpoints: Seizure reduction: seizure free intervals, reduction of days with<br /><br>myoclonus, number of generalised tonic-clonic seizures and seizure recurrence<br /><br>within a year (with aid of seizure diary).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>