Manipulation of Arterial Pressure Early in Non Thrombolysed Acute Ischemic Stroke: Effects on Death and Neurological Disability

Hospital de Clinicas de Porto Alegre1 site in 1 country240 target enrollmentJanuary 2008

ConditionsStroke, Acute

InterventionsEsmolol, Sodium Nitroprussiate (NPS) or Norepinephrine (NOR)Esmolol, NPS or NOR manipulation of SAP

DrugsEsmolol, Sodium Nitroprussiate (NPS) or Norepinephrine (NOR)Esmolol, NPS or NOR manipulation of SAP

Overview

Phase: Not Applicable
Intervention: Esmolol, Sodium Nitroprussiate (NPS) or Norepinephrine (NOR)
Conditions: Stroke, Acute
Sponsor: Hospital de Clinicas de Porto Alegre
Enrollment: 240
Locations: 1
Primary Endpoint: Ranking score and mortality
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This is a controlled clinical trial among non thrombolysed acute ischemic stroke patients to determine the effects of three levels of arterial pressure on death and neurological disability. After the admission in the vascular unit of the Emergency Department the patients are randomized to maintain during the first 24h the Systolic Arterial Pressure in tree levels of pressure: 140 to 160 mmHg; 161 to 180 mmHg and 181 to 200 mmHg. The end point of the study is the Modified Rankin score and mortality in three month after the discharge.

Detailed Description

To maintain the tree levels of systolic arterial pressure during de first 24h we will use one of the two strategies:1) infusion of 500 to 1000ml of saline solution and/or norepinephrine solution to increase de systolic pressure or 2) infusion of esmolol or nitroprussiate solution to decrease de pressure. Every patient will have a transcranial doppler study in the first 24h to measure the mean velocity of cerebral arteries.

Registry

clinicaltrials.gov

Start Date

January 2008

End Date

December 2010

Last Updated

16 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Hospital de Clinicas de Porto Alegre

Eligibility Criteria

Inclusion Criteria

•Patients 18 years or older, with the first Acute Ischemic Stroke within the first 6 hours of the symptoms and not candidate to thrombolysis
•We will also include patients with previous Ischemic Stroke with Ranking score 0 or 1