Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Apical Periodontitis
- Sponsor
- University of Pennsylvania
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Peri-radicular Healing
- Status
- Recruiting
- Last Updated
- 8 months ago
Overview
Brief Summary
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the osteotomy site to promote bone formation. Healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Provision of signed and dated informed consent form.
- •Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits.
- •Male or Female age \>18 years old.
- •In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery.
- •Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5)
- •Intact coronal restorations with no evidence of leakage or caries under the restoration.
Exclusion Criteria
- •Suspected root fractures.
- •ASA classification 3 or greater.
- •Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5).
- •Patients with history of Oral or IV Bisphosphonate use.
- •Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.
Outcomes
Primary Outcomes
Peri-radicular Healing
Time Frame: 12 and 24 months
Evaluate Peri-radicular healing after Endodontic Microsurgery with the use of autologous L-PRF plug.