Brief Cognitive Behavioral Therapy to Treat Itch Rumination "Itch CBT" in Eczema

Not Applicable

Completed

• Conditions: Atopic Dermatitis
• Interventions: Behavioral: Itch CBT

• Registration Number: NCT04486742
• Lead Sponsor: Northwestern University

Brief Summary

The main purpose of this study is to adapt cognitive behavior therapy (CBT) to improve itch in children with eczema.

Detailed Description

Eczema is characterized by chronic itch. Many children develop a chronic focus (rumination) on their itch. Rumination is a maladaptive method of responding to distress, in which the individual thinks obsessively about the source of distress. The rumination on chronic itch in eczema can have detrimental effects on one's quality of life, as well as induce significant anxiety about when itch will return, how long it will last, and how it will affect physical and social functioning.

Cognitive behavior therapy (CBT) is a frontline treatment for rumination, as it focuses on teaching strategies so that the individual can examine distressing thoughts objectively and determine their validity, replace negative thinking patterns with more adaptive thought patterns, and increase the individual's awareness to their problematic thought patterns. Additionally, CBT helps the individual to implement behavioral strategies to cope with possibly anxiety-inducing situations, such as scratching while trying to go to sleep.

The investigators hypothesize that an Itch CBT intervention is an effective, non-medication-based, easy to implement strategy to improve itch in children with eczema.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2020-07-14
• Study First Submitted QC: 2020-07-21
• Study First Posted: 2020-07-27
• Study Start: 2020-09-01
• Primary Completion: 2021-12-21
• Study Completion: 2021-12-21
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-06
• Last Update Posted: 2023-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Moderate to severe atopic dermatitis [assessed by Patient Oriented Eczema Measure (POEM)score of >-8 OR NRS itch score of >= 4].
• English speaking.
• Currently receiving treatment at Lurie Children's Hospital for atopic dermatitis.
• Parent or guardian available to participate in protocol.
• Have sufficient technology (e.g., cell phone, computer, tablet, etc.) that can be used to access Zoom conference technology for telemedicine visits.

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Exclusion Criteria

• Inability to comprehend and complete questionnaires.
• History of intellectual disability or psychosis.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Itch CBT Arm	Itch CBT	Participants randomized to the Itch CBT Arm will participate in 4 weekly telehealth sessions with a therapist to address common areas of anxiety related to atopic dermatitis.

Primary Outcome Measures

Name	Time	Method
Itch Severity Numerical Rating Scale	Baseline to Week 4	Numerical rating scale to assess itch severity, scale of 0-10, higher score means higher itch severity and worse outcome.

Secondary Outcome Measures

Name	Time	Method
PROMIS Anxiety and Depression	Baseline to Week 4	Questionnaire to assess anxiety and depression symptoms in pediatric populations
PROMIS Pediatric Itch - Short Form 1 (2+6)	Baseline to Week 4	Questionnaire to assess level and severity of itch and common disturbances due to itch (social, emotional, physical)
Itch Rumination Questionnaire	Baseline to Week 4	Questionnaire to assess common fear and anxiety around itch

Trial Locations

Locations (1)

Lurie Children's Hospital; 🇺🇸 Chicago, Illinois, United States