Peripheral Sensory Input in Central Post Stroke Pain (CPSP)

Not Applicable

Completed

• Conditions: Central Post Stroke Pain
• Interventions: Drug: Ultrasound-guided peripheral nerve block with 2% lidocaine

• Registration Number: NCT02148588
• Lead Sponsor: Washington University School of Medicine

Brief Summary

Prospective, open-label study in 10 patients with Central Post Stroke Pain (CPSP). The study will evaluate the effects of peripheral nerve blockade on spontaneous pain and evoked thermal and mechanical responses in CPSP, and assesses the associated local anesthetic pharmacokinetics.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-05-15
• Study First Submitted QC: 2014-05-27
• Study First Posted: 2014-05-28
• Study Start: 2014-08
• Primary Completion: 2016-12-15
• Study Completion: 2017-01-25
• Results First Submitted: 2018-01-31
• Status Verified: 2018-04
• Results First Submitted QC: 2018-04-30
• Last Update Submitted: 2018-04-30
• Results First Posted: 2018-05-02
• Last Update Posted: 2018-05-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Pain testing	Ultrasound-guided peripheral nerve block with 2% lidocaine	Completion of NPSI questionnaire Sensory mapping of the affected limb Quantitative Sensory Testing Patients will have a peripheral nerve blockade

Primary Outcome Measures

Name	Time	Method
Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block.	baseline and 30 minutes	Reduction in spontaneous pain intensity in the painful extremity from baseline to 30 minutes after a peripheral nerve block.Spontaneous pain intensity was measured on 0-10 numerical rating scale (NRS), where 0 represents "no pain", and 10 represents "worst pain imaginable"

Secondary Outcome Measures

Name	Time	Method
Change in the Intensity of Cold Sensation	baseline and 30 min	The intensity of cold sensation (application of roller cooled down to 20 degrees Celsius) was measured on 0-10 scale, where 5 represents "normal" sensation (comparable to contralateral non-painful extremity). Higher scores indicate increased sensitivity (10= painful cold); lower scores represent reduced sensitivity (0=no cold sensation)
Change in the Intensity of Warm Sensation	baseline and 30 min	The intensity of warm sensation (application of roller heated up to 40 degrees Celsius) was measured on 0-10 scale, where 5 represents "normal" sensation (comparable to contralateral non-painful extremity). Higher scores indicate increased sensitivity (10= painful hot); lower scores represent reduced sensitivity (0=no warmth sensation)
Change in the Intensity of Pinprick Sensation	baseline and 30 min	The intensity of pinprick sensation (application of Semmes-Weinstein monofilament #6.1, \~100g target force) was measured on 0-10 scale, where 5 represents "normal" sensation (comparable to contralateral non-painful extremity). Higher scores indicate increased sensitivity (10= painful sharp); lower scores represent reduced sensitivity (0=no pricking sensation)
Change in the Intensity of Brush Sensation	baseline and 30 min	The intensity of brush sensation (application of SENSELab Brush-05) was measured on 0-10 scale, where 5 represents "normal" sensation (comparable to contralateral non-painful extremity). Higher scores indicate increased sensitivity (10= painful brushing sensation); lower scores represent reduced sensitivity (0=no brushing sensation)
Reported Pain/Dysesthesia Descriptors on NPSI Questionnaire	baseline and 40 min	Composite scores on NPSI (Neuropathic Pain Symptom Inventory) questionnaire before and 40 minutes after the peripheral nerve block.; The NPSI assesses participant ranking of specific neuropathic pain descriptors, each ranked on a 0-10 scale, where 0 represents no burning/squeezing/electric shocks (etc), and 10 represents worst burning/squeezing/electric shocks (etc).; The scores on individual questions are grouped (averaged) into the three following subscales (each subscale scores ranging from 0 to 10): * Burning pain; * Paroxysmal pain; * Paresthesia/dysesthesia

Trial Locations

Locations (1)

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States