How "Central" is Central Post-stroke Pain? Investigating the Role of Peripheral Sensory Input in Maintaining Central Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block.
研究概览
简要总结
Prospective, open-label study in 10 patients with Central Post Stroke Pain (CPSP). The study will evaluate the effects of peripheral nerve blockade on spontaneous pain and evoked thermal and mechanical responses in CPSP, and assesses the associated local anesthetic pharmacokinetics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Pain testing
Completion of NPSI questionnaire
Sensory mapping of the affected limb
Quantitative Sensory Testing
Patients will have a peripheral nerve blockade
干预措施: Ultrasound-guided peripheral nerve block with 2% lidocaine (Drug)
结局指标
主要结局
Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block.
时间窗: baseline and 30 minutes
Reduction in spontaneous pain intensity in the painful extremity from baseline to 30 minutes after a peripheral nerve block.Spontaneous pain intensity was measured on 0-10 numerical rating scale (NRS), where 0 represents "no pain", and 10 represents "worst pain imaginable"
次要结局
- Change in the Intensity of Cold Sensation(baseline and 30 min)
- Change in the Intensity of Warm Sensation(baseline and 30 min)
- Change in the Intensity of Pinprick Sensation(baseline and 30 min)
- Change in the Intensity of Brush Sensation(baseline and 30 min)
- Reported Pain/Dysesthesia Descriptors on NPSI Questionnaire(baseline and 40 min)
研究者
simon.haroutounian
Assistant Professor
Washington University School of Medicine