Comparison of Tidal Volume Between Pediatric Anaesthesia and Paediatric Intensive Care Patients

Recruiting

• Conditions: Protective Ventilation
• Interventions: Other: Data from intensive care records for ventilation setting screening; Other: Data from anaesthesia records for ventilation setting screening

• Registration Number: NCT03877354
• Lead Sponsor: Brno University Hospital

Brief Summary

Paediatric anaesthesiology and paediatric intensive care unit data will be retrospectively screened for the data regarding mechanical ventilation. The primary aim will be the tidal volume setting and the secondary the level of positive end-expiration pressure (PEEP) according to the inspired oxygen fraction (FIO2), and the level of driving pressure.

Detailed Description

Protective positive pressure ventilation (tidal volume ≤6 mL/kg) in adult patients in intensive care is currently considered as a standard procedure. It is associated with a reduction of morbidity and positive outcome. In paediatric patients there are available only limited information related to the size of the tidal volume and it is recommended to use the volume between 5 and 8 mL per kg for the whole spectrum of ages of pediatric patients. The aim of this retrospective observational study is to evaluate the tidal volumes used in clinical practice in pediatric patients during general anesthesia and compared it to the tidal volumes used in paediatric critical care. Data will be harvested from the anaesthesiology records and from the paediatric intensive care unit charts. The tidal volume will calculated per kg of actual weight.

Study Timeline

• Study First Submitted: 2019-03-09
• Study First Submitted QC: 2019-03-14
• Study First Posted: 2019-03-15
• Study Start: 2019-04-01
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-26
• Last Update Posted: 2023-07-27
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Paediatric patients on mechanical ventilation in anaesthesia department
• Paediatric patients on mechanical ventilation in intensive care department
• In selected study period between 1.1.2018 - 31.1.2019

Exclusion Criteria

• Age outside selected limits
• Insufficient data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Paediatric patients intensive care	Data from intensive care records for ventilation setting screening	Paediatric patients admitted to the paediatric intensive care unit with the need for mechanical ventilation in the selected time period
Paediatric patients anaesthesia	Data from anaesthesia records for ventilation setting screening	Paediatric patients who underwent diagnostic or surgical procedure under general anaesthesia with the need for mechanical ventilation in the selected time period.

Primary Outcome Measures

Name	Time	Method
Tidal volume	Intraoperative period	Tidal volume will be evaluated in the paediatric patients in anaesthesia and in intensive care unit

Secondary Outcome Measures

Name	Time	Method
Driving pressure	Intraoperative period	Driving pressure will be calculated from peak pressure minus PEEP in patients on mechanical ventilation in anaesthesia and in intensive care unit
Positive end-expiratory pressure settings according to the inspiration fraction of oxygen	Intraoperative period	Positive end-expiratory pressure will be evaluated in the paediatric patients in anaesthesia and in intensive care unit

Trial Locations

Locations (1)

University Hospital Brno; 🇨🇿 Brno, State, Czechia