Bioavailability of Fish Oils: Emulsified vs. Capsular Triglyceride
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Area under the curve for phospholipid fatty acids
研究概览
简要总结
The primary objective of this investigation is to determine the relative percentage and rate of incorporation of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and total omega-3 (n-3) fatty acids after ingestion of 4 emulsified flavored triglyceride fish oil supplements versus an encapsulated triglyceride in defined plasma lipid pools.
The primary endpoints to be evaluated include the fatty acid composition of plasma lipids before and after consumption of a single dose of emulsified triglyceride based fish oil and triglyceride of similar n-3 compositions in capsule form. The investigators will measure changes in plasma phospholipid, and chylomicron fatty acids.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults ages 18 to
- •Body mass index between 22 and 32 kg/m
- •Medical history (interview) demonstrating good health.
- •Consumption of a typical American diet with no unusual dietary habits.
- •Willingness to comply with the study protocol.
- •Low reported n-3 intake (<100 mg/d) on the Omega-3 Checklist
排除标准
- •Any active, uncontrolled medical problem.
- •Consumption of essential fatty acid supplements within the past 6 months.
- •Use of lipid lowering drugs.
- •Fish consumption greater than 1 fish meal per week
研究组 & 干预措施
Nordic Omega-3 Softgel
4 softgels
干预措施: Nordic Omega-3 Softgel (Dietary Supplement)
Coromega Omega-3 Squeeze
5.03 g
干预措施: Coromega Omega-3 Squeeze (Dietary Supplement)
Coromega Nectar
12.22 g
干预措施: Coromega Nectar (Dietary Supplement)
Barleans Swirl
17.45 g
干预措施: Barleans Swirl (Dietary Supplement)
结局指标
主要结局
Area under the curve for phospholipid fatty acids
时间窗: 48 hours
Evaluation of the bioavailability of fatty acids from fish oil supplements
次要结局
- Area under the curve for chylomicron fatty acids(48 hours)