Prospective, Randomised, Placebo-controlled Study of Polyvalent Intravenous Immunoglobulins for the Treatment of Primary Sjögren's Syndrome Associated Painful Sensory Neuropathies
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Improvement of at least 20% over placebo with the R-DS scale (Rasch-built Overall Disability Scale)
研究概览
简要总结
To summarise, the peripheral neurological complications experienced by patients with primary Sjögren's syndrome are particularly bothersome since they are common and often result in significant disability related to pain or motor impairment. There is currently no standard treatment for these patients.
As these neuropathies are caused by an immune system dysfunction, which is related to a variety of different pathogenic mechanisms, the use of immunosuppressant or immunomodulator drugs is often justified.
With the exception of the vascularitis-related multiplex mononeuropathies, other pSS-related neuropathies could be suitable candidates for IV Ig treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years and < 80 years
- •Primary Sjögren's syndrome defined as per the European and American criteria (5)
- •Peripheral neuropathy clinically defined:
- •Pure sensitive (lymph node disease) or sensorimotor neuropathies
- •Proved EMG
- •Renal function, and viral evaluation (VIH and hepatitis serology) :
- •*Clairance > 50 (In case of biological abnormality, the second dosage can be scheduled within 2 weeks)
- •Effective contraception during the study period
- •Patient capable of understanding information about the study and of giving his/her consent
- •Patient informed of the preliminary medical exam results
- •Patient with healthcare insurance
- •Written consent signed
排除标准
- •Peripheral neurological damage of the type vascularitis-related multiplex mononeuropathy
- •Small fibers neuropathy
- •Neuropathy suspected of being related to alcohol, diabetes or post-chemotherapy
- •Chronic viral infection (HCV, HBV, HIV, etc.)
- •Prior treatment with polyvalent intravenous immunoglobulins in the 6 months preceding the study
- •Corticosteroid treatment at a dose greater than 20 mg/d of prednisone equivalent or no stable dose for at least 1 month before inclusion
- •Conventional immunosuppressant treatment with azathioprin, cyclophosphamide or mycophenolate mofetil on-going or interrupted less than one month before inclusion
- •Rituximab or other biotherapy (belimumab, tocilizumab, ...) less than 6 months before the start of the study treatment
- •Immunomodulating treatment with methotrexate no stable dose for at least 2 months before inclusion
- •Hydroxychloroquine no stable dose for at least 3 months before inclusion
- •Pilocarpine hydrochloride secretagogue treatment no stable dose for at least one month before inclusion
- •Treatment with amitriptyline, clomipramine, carbamazepine, clonazepam, pregabaline, duloxetine or gabapentine if the dose has not been stable for at least one month before inclusion (possible dose reduction to be documented).
- •renal clairance < 50 ml/mn
- •HIV seropositivity
- •HBV, or HCV viral replication
- •Contraindication to the use of IV Ig: h Hypersensitivity to the active substance or to any of the excipients; hypersensitivity to human immunoglobulins, especially in patients with antibodies against IgA; patients with hyperprolinaemia.
- •Contraindication to the use of Nacl
- •Immunization with live attenuated vaccine within 2 weeks prior to inclusion
- •Participation in a clinical study with an investigational product with an exclusion period
- •Women of child bearing potential or intends to become pregnant, unless they are using an effective method of birth control* and a βHCG blood test negative
- •Pregnant or nursing (lactating) women
- •Patient under legal guardianship
- •Prisoners
研究组 & 干预措施
Privigen
TThe treatment (IV Ig, 100mg/ml at the dose of 2g/kg of body weight) will be administered by perfusion every 6 weeks, with a total of 3 perfusions administered (W0, W4, W8).
干预措施: Privigen® 100mg/ml at the dose of 2g/kg of body weight (Drug)
Placebo
The treatment (NaCl 0,9% 20 ml/kg) will be administered by perfusion every 4 weeks, with a total of 3 perfusions administered (W0, W4, W8).
干预措施: NaCl 0,9% (Drug)
结局指标
主要结局
Improvement of at least 20% over placebo with the R-DS scale (Rasch-built Overall Disability Scale)
时间窗: At week 11
Improvement of at least 20% over placebo of numerical Pain Scale
时间窗: At week 11
次要结局
- Evaluate patient's quality of life, fatigue, and Sicca syndrome intensity.(Weeks 11)
- Evaluate intensity of the IV Ig effect on neurological scales(Weeks 11)
- Evaluate patient's quality of life, fatigue, and Sicca syndrome intensity. intensity.(Weeks11)