Pathophysiology clarification of spasmodic dysphonia by functional MRI - Analysis of spasmodic dysphonia by fMRI

We found overactivation in the left sensorimotor cortex and the left thalamus in SD patients, suggesting that voice perception activates different neural systems between SD patients and healthy participants. For SD patients, moreover, the magnitude of sensorimotor activation showed a significant positive correlation with symptom severity measured by voice handicap index-10, suggesting that signals from the sensorimotor cortex can be a new biomarker for assessing disease severity.