Pathophysiology clarification of spasmodic dysphonia by functional MRI
Not Applicable
- Conditions
- Spasmodic dysphonia
- Registration Number
- JPRN-UMIN000016807
- Lead Sponsor
- Graduate School of Medicine, Kyoto University
- Brief Summary
We found overactivation in the left sensorimotor cortex and the left thalamus in SD patients, suggesting that voice perception activates different neural systems between SD patients and healthy participants. For SD patients, moreover, the magnitude of sensorimotor activation showed a significant positive correlation with symptom severity measured by voice handicap index-10, suggesting that signals from the sensorimotor cortex can be a new biomarker for assessing disease severity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
Not provided
Exclusion Criteria
Patients of dysphasia, organic disease of vocal code History of botulinum toxin treatment less than 6 months before participation Patients of mental disease Patients of abuse of alchocol or medication
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bold signal recorded by fMRI
- Secondary Outcome Measures
Name Time Method Voice Handicap Index