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临床试验/NCT05653076
NCT05653076招募中不适用

Hibiscus Sabdariffa Extract Effect on Neuromuscular Performance After Intense Resistance Exercise: a Randomized, Placebo-controlled, Crossover Study

Universidad de Granada2 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2023年1月23日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
25
试验地点
2
主要终点
Explosive strength

研究概览

简要总结

Exercise-induced muscle damage (EIMD) is a transient problem that athletes face after performing more intense and/or prolonged exercise than they are used to. EIMD is accompanied by an increase in the production of reactive oxygen species and a decrease in the antioxidant capacity of the organism. This phenomenon decreases the performance capacity of athletes due to impaired muscle strength and range of motion. Among the strategies to reduce EIMD, the use of nutritional strategies rich in antioxidants such as polyphenols stands out. In this sense, the extract of Hibiscus sabdariffa is particularly rich in polyphenolic antioxidants, among which anthocyanins stand out. Previous studies have concluded that the administration of an extract of Hibiscus sabdariffa can prevent overtraining syndrome by reducing the levels of oxidizing agents and increasing the body's antioxidant defenses. However, despite the fact that Hibiscus sabdariffa extract has been shown to be safe for humans to ingest and have various health benefits, to our knowledge, no studies have evaluated its ability to minimize neuromuscular performance impairment that occurs after performing an intense session of strength training. Based on previous evidence, we hypothesize that supplementation with an extract of Hibiscus sabdariffa will improve neuromuscular performance after performing intense resistance exercise in young (18-35 years) and trained adults, with at least 1 year of experience training. strength. The design of this study is crossover, randomized and placebo controlled, where each individual will act as her own control. The neuromuscular performance parameters to be evaluated will be: i) explosive strength - main variable, in terms of countermovement jump height (CMJ); ii) the maximum dynamic force; and iii) the ability to change direction, all of them 24h and 72h after a high-intensity strength training session. If our hypothesis is confirmed, the results of our study would not only have an impact at a scientific level but also at a commercial level through the development of supplements and/or functional foods.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
Triple (Participant, Investigator, Outcomes Assessor)

盲法说明

triple-blinded

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
Male
接受健康志愿者
是

入选标准

  • •Age: 18-35 years.
  • •Body mass index: 18.5-30 kg/m2
  • •Be able to understand the instructions, objectives, and protocol of the study.
  • •Trained in some force sports discipline ≥1 year prior to the study and accustomed to carrying out the exercises of the evaluation protocol.

排除标准

  • •History of a major adverse cardiovascular event, renal failure, cirrhosis, eating disorder, polycystic ovarian syndrome, weight control surgery, type 2 diabetes mellitus, or HIV/AIDS.
  • •Any chronic pathology in which the intake of nutritional supplements is not recommended.
  • •Any condition that, in the investigator's judgment, impairs the ability to participate in the study or represents a personal risk to the participant.
  • •Use of medications that may affect the results of the study.
  • •Unstable body weight for 3 months prior to study start (>4 kg weight gain or loss)
  • •Routine use of teas/infusions/supplements rich in polyphenols.
  • •Pregnancy and lactation.
  • •Active tobacco or illicit drug use or history of treatment for alcohol abuse.
  • •To be on a special diet or prescribed for other reasons (eg celiac disease).

研究组 & 干预措施

Placebo

Placebo Comparator

Microcrystalline cellulose

干预措施: Hibiscus sabdariffa extract (Dietary Supplement)

Hibiscus sabdariffa extract

Experimental

520 mg of Hibiscus sabdariffa extract

干预措施: Hibiscus sabdariffa extract (Dietary Supplement)

结局指标

主要结局

Explosive strength

时间窗: 1 day (24h) after a bout of an intense resistance exercise

It will be measured through the height of the countermovement jump (CMJ)

Maximal dynamic force

时间窗: 1 day (24h) after a bout of an intense resistance exercise

It will be measured by means of a CMJ with a load

Ability to change direction

时间窗: 1 day (24h) after a bout of an intense resistance exercise

It will be measured by means of a CMJ with a load

次要结局

  • Maximal dynamic force(3 days (72h) after a bout of an intense resistance exercise)
  • Ability to change direction(3 days (72h) after a bout of an intense resistance exercise)
  • Explosive strength(3 days (72h) after a bout of an intense resistance exercise)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Francisco Javier Osuna-Prieto

Principal Investigator

Universidad de Granada

研究点 (2)

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