The Correlation Study Between Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- the incidence of stroke in a follow-up period
研究概览
简要总结
Correlation study about Blood Pressure Variability and the prognosis of ischemic stroke with intracranial artery stenosis
详细描述
Extracranial atherosclerotic stenosis is the main reason for the European and American white ischemic stroke and transient ischemic attack,while Atherosclerotic intracranial arterial stenosis is an important reason for Asian patients with stroke ,accounting for the 33% to 51% of a etiology ratio.The latest research suggests that varying degrees of blood pressure variability can affect the risk of stroke.This study observe the relationship between blood pressure variability and prognosis of ischemic stroke patients with intracranial arterial stenosis,with cranial magnetic resonance imaging (MRI + DWI),magnetic resonance angiography and Trans-cranial Doppler(TCD) .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age : ≥ 18 years of age , ≤ 75 years old
- •with intracranial artery stenosis in ischemic stroke
- •the diagnosis of ischemic cerebrovascular disease are in line with the diagnostic criteria developed by the Chinese Medical Association Fourth National Cerebrovascular Disease Conference
- •the patient admitted to hospital receive at least one examination like cranial MRI + DWI, MRA and TCD examination, clearly associated with intracranial arterial stenosis
- •MRS score ≤ 3 points
排除标准
- •vascular , cardiac , and unknown causes or other reasons lead to ischemic stroke
- •associated with significant emotional disorders, cognitive impairment or other mental disorders can not be partners
- •severe occlusion of Unilateral intracranial arteries ( over 90 % ) or bilateral stenosis more than 70%
- •With extracranial artery stenosis, especially carotid and vertebral artery stenosis .
- •patients with extracranial artery stenosis or patients previously done neck or intracranial artery balloon dilation , stent forming surgery or carotid endarterectomy
- •Incomplete clinical data collection in patients
研究组 & 干预措施
amlodipine
The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
干预措施: Amlodipine (Drug)
amlodipine
The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
干预措施: Aspirin or Clopidogrel (Drug)
amlodipine
The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
干预措施: Atorvastatin (Drug)
ACEI / ARB
ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)
干预措施: ACEI / ARB (Drug)
ACEI / ARB
ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)
干预措施: Aspirin or Clopidogrel (Drug)
ACEI / ARB
ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)
干预措施: Atorvastatin (Drug)
结局指标
主要结局
the incidence of stroke in a follow-up period
时间窗: one year
次要结局
- blood pressure during the compliance status in a follow-up(one year)
- patients with blood pressure variability in a follow-up(one year)
- Changes in intracranial arterial stenosis and stiffness before and after the follow-up(one year)
- Other vascular events ( acute ischemic heart disease or vascular death )(one year)
研究者
Shi Guowen
Principal Investigator
RenJi Hospital