Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing In Vitro Fertilization Cycles
- Conditions
- OligoasthenospermiaSperm Quality
- Interventions
- Dietary Supplement: myo-inositol + folic acid
- Registration Number
- NCT01560065
- Lead Sponsor
- AGUNCO Obstetrics and Gynecology Centre
- Brief Summary
Myo-Inositol (MI) is a precursors for the synthesis of phosphatidylinositol polyphosphates (PIPs). In male reproduction, it was shown that MI concentration in the seminiferous tubules is higher than in serum and it was increasing during the movement through the epididymis and the deferent duct. In the present study, the role of myo-inositol has been investigated as a possible antioxidant agent for the systemic treatment of male infertility and the improvement of the sperm's quality.
Samples of seminal fluid were obtained from two groups of patients undergoing to a IVF cycle: healthy subjects and subjects with oligoasthenospermia (OA, \< 15 mil/ml). The collected samples were submitted to optic microscopy in order to evaluate semen's volume, spermatozoa's number and motility, during the initial semen analysis and after density gradient separation method; these parameters were evaluated before and after the administration of 4000mg/die of myo-inositol associated to 400 µg of folic acid for three months.
These values were compared with samples of seminal fluid of healthy patients undergoing to a IVF cycle for a female cause of infertility (control group).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- Not specified
- 3-5 days of sexual abstinence
- systemic and endocrine diseases
- genital infections
- history of cryptorchidism or varicocele
- microorchidism
- hormonal treatment in the last six months
- alcohol intake, cigarette smoke and/or drug abuse
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Normospermic patients myo-inositol + folic acid - Oligoasthenospermic patients myo-inositol + folic acid -
- Primary Outcome Measures
Name Time Method Spermatozoa count Semen volume Number of spermatozoa after density gradient separation method Spermatozoa progressive motility
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Catania - Department of Surgery - Section of Obstetrics and Gynecology -Center of Physiopathology of Reproduction
🇮🇹Catania, Italy