The title given on the patient information sheet is: CONservative TReatment of Appendicitis in Children a randomised controlled Trial CONTRACT (Feasibility)

niversity Hospital Southampton NHS Foundation Trust0 个研究点目标入组 57 人开始时间: 2017年2月8日最近更新: 2023年6月20日

适应症

试验速览

2020 Other publications in https://pubmed.ncbi.nlm.nih.gov/32228534/ qualitative study (added 27/11/2020) 2018 Protocol article in https://pubmed.ncbi.nlm.nih.gov/29499722/ protocol (added 27/11/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33441315/ results (added 18/01/2021) 2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33630732/ protocol (added 26/02/2021) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36746524/ (added 07/02/2023) 2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/37286916/ (added 08/06/2023)

•1. Child age 4 – 15 years (<16 years and >3 years)
•2. Clinical diagnosis, either with or without radiological assessment, of acute appendicitis which prior to study commencement would be treated with appendicectomy
•3. Written informed parental consent, with child assent if appropriate

•1. Clinical signs or radiological findings to suggest perforated appendicitis
•2. Presentation with appendix mass
•3. Previous episode of appendicitis or appendix mass treated non-operatively
•4. Major anaesthetic risk precluding allocation to the appendicectomy arm
•5. Known antibiotic allergy preventing allocation to non-operative treatment arm
•6. Antibiotic treatment started at referring institution (defined as 2 or more doses administered)
•7. Cystic fibrosis
•8. Positive pregnancy test
•9. Current treatment for malignancy

发起方

niversity Hospital Southampton NHS Foundation Trust