Should Colon or Non-colon Originated Lesions be Distinguished?

Phase 1

• Conditions: Acute Lower Gastrointestinal Dysfunction

• Registration Number: NCT02939508
• Lead Sponsor: Chinese Medical Association

Brief Summary

This prospective study was designed to compare the difference of effects of conventional treatment, medicine intervention, endoscopic therapy, and surgery between colon originated and non-colon originated ALGID in critical patients, in order to alert doctors to differ the treatment of the two ALGID and provide basis for treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07
• Status Verified: 2016-10
• Study First Submitted: 2016-10-07
• Study First Submitted QC: 2016-10-18
• Last Update Submitted: 2016-10-18
• Study First Posted: 2016-10-20
• Last Update Posted: 2016-10-20
• Primary Completion: 2017-07
• Study Completion: 2017-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 158

Inclusion Criteria

1. Patients in our ICU aged 18-75 years.
2. Patients with a confirmed diagnosis of ALGID.

Exclusion Criteria

1. mechanical intestinal obstruction (including tumor, stercoral obstruction etc.)
2. gastrointestinal hemorrhage within 72 hours.
3. history of inflammatory bowel disease (ulcerative colitis or Crohn's disease) or radiation enteritis.
4. pregnancy.
5. contraindications of neostigmine administration.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
28-day mortality after admission	1-28 day after admission
ICU mortality, n (%)	1-28 day after ICU admission

Secondary Outcome Measures

Name	Time	Method
intra-abdominal pressure	1-28 day after admission
ICU stage, (day)	1-60 day after ICU admission
Hospitalization, (day)	1-60 day after admission
Abdominal compartment syndrome	1-28 day after admission

Trial Locations

Locations (1)

Jinling Hospital; 🇨🇳 Nanjing, Jiangsu, China