Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- PAI-1 expression level in scalp skin biopsy samples
研究概览
简要总结
This study will investigate whether subjects who suffer from hair loss have increased levels of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be determined in subjects without hair loss and in subjects with non-scarring hair loss, including androgenetic alopecia, telogen effluvium and alopecia areata.
详细描述
This study will compare the levels of PAI-1 expression in subjects with different forms of non-scarring hair loss and in these subjects vs normal age-matched controls. Hair loss subjects will have their Northwestern Memorial Hospital and Northwestern Medical Faculty Foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. All subjects will have a 4 mm punch biopsy on the scalp. Tissue PAI-1 levels from scalp skin biopsies will be determined by immunohistochemical staining. Samples will be kept for approximately 15 years, after which time unused samples will be destroyed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age-matched control subjects who do not have a history of hair loss
- •A clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium, alopecia areata or normal scalp skin
- •All subjects must have given signed, informed consent prior to registration in study
排除标准
- •History of previous hair transplantation
- •Current and past use of medications topically on the scalp
- •Clinical or pathologic diagnosis of a scarring alopecia
- •History of inflammatory conditions of the scalp such as psoriasis
结局指标
主要结局
PAI-1 expression level in scalp skin biopsy samples
时间窗: Baseline
Tissue PAI-1 expression levels will be determined by immunohistochemistry, a three-layer biotin-strepavidin system. Positive PAI-1 expression per total tissue area will be quantified using the color-picker function in imaging software.The PAI-1 expression found in normal scalps will be compared to those found in scalps with hair loss.
次要结局
未报告次要终点
研究者
Maria Colavincenzo
Assistant Professor in Dermatology
Northwestern University