Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

Not Applicable

Completed

• Conditions: Blood Iron Isotope Enrichment
• Interventions: Other: 586/8x87 brown; Other: 586/8x87 white; Other: BAT 881; Other: 586/8

• Registration Number: NCT01472484
• Lead Sponsor: Swiss Federal Institute of Technology

Brief Summary

Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA. These plants have normal phosphate levels, but reduced PA phosphate due to various modifications of the biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of them exhibiting reduced yield and seed germination. However, the lpa bean isolated by Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean PA concentration without any defects in terms of growth and yield.

Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the development of a variety which has the potential to improve the iron status of bean consuming populations.

The following study will evaluate the relative impact of PA and PP on iron absorption from beans by comparing iron absorption from four different bean varieties. Iron absorption from a bean with normal PA concentration and high PP concentration will be compared to iron absorption from a bean with normal PA and low PP concentration as well as to two lpa varieties, one with high and one with low PP concentration.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-11-09
• Study First Submitted QC: 2011-11-15
• Study First Posted: 2011-11-16
• Study Start: 2011-12
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Status Verified: 2012-06
• Last Update Submitted: 2012-06-18
• Last Update Posted: 2012-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• Non-pregnant, non-lactating women
• Between 18 and 40 years
• Below 65kg

Exclusion Criteria

• Metabolic, chronic and gastro-intestinal disease
• Long-term medication
• Blood donation within 6 month before the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
lpa with high polyphenol	586/8x87 brown	-
lpa with low polyphenol	586/8x87 white	-
control bean with high polyphenol	BAT 881	-
control bean with low polyphenol	586/8	-

Primary Outcome Measures

Name	Time	Method
Shift in iron isotopic composition in blood after consumption of different bean varieties	1 month

Trial Locations

Locations (1)

ETH; 🇨🇭 Zurich, Switzerland