The Association Between Sedentary Behaviour and Cardiometabolic Health in Trained Athletes

Completed

• Conditions: Physical Activity; Athletes; Sedentary Behavior; Cardiometabolic Health
• Interventions: Behavioral: Physical activity and sedentary behaviour

• Registration Number: NCT04711928
• Lead Sponsor: Hasselt University

Brief Summary

Physical inactivity is one of the major contributing factors for the development of chronic diseases and highly correlated with increased all-cause mortality. In the last decade an exponential growth in research concerned with the study of sedentary behaviour and the potential for detrimental effects on health have been published. In this field increasing evidence suggests that prolonged periods of sedentary time, independent of the amount of physical activity, also increases the risk for the development of several chronic conditions and all-cause mortality. Here, sedentary behaviour is defined as "any waking behaviour, characterized by a low energy expenditure (≤1.5 METs), while being in a sitting or reclining posture". Interestingly, the advised moderate-to-vigorous bouts of exercise recommended by the various guidelines cannot compensate the negative impact on health risks arising from prolonged periods of sitting. In other words, it seems that people compensate their total amount of physical activity after exercise training by decreasing their physical activity levels throughout the rest of the day. Here, it appears that frequent, even low-intensity interruptions of periods of sitting are required for good cardiometabolic health. Therefore, not only physical activity but also prolonged sitting should be targeted to optimize cardiometabolic health. Nevertheless, a recent harmonized meta-syntheses indicated that the association between self-reported sitting with all-cause and cardiovascular disease mortality are only partially independent of physical activity, but were particularly evident in those who undertake insufficient physical activity (\<150min/week). However, it is unclear whether high amounts of objectively measured physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. In addition, it is still unclear whether high amounts of physical activity can preserve a healthy cardiometabolic risk profile, despite prolonged sitting. Therefore, in this study we want to investigate the association between sedentary behaviour, physical activity and cardiometabolic health in highly physically active adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-10
• Study First Submitted: 2021-01-13
• Study First Submitted QC: 2021-01-14
• Study First Posted: 2021-01-15
• Primary Completion: 2021-08-01
• Study Completion: 2021-10-01
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-14
• Last Update Posted: 2022-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Active individuals with at least 4 training hours per week

Exclusion Criteria

• pregnancy
• Any known contradiction for physical activity
• Systolic blood pressure >160mmHg, diastolic blood pressure >100mmHg
• More than 20 alcohol consumptions per week
• Participants diagnosed with any known chronic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Trained athletes	Physical activity and sedentary behaviour	Active individuals with at least 4 training hours per week.

Primary Outcome Measures

Name	Time	Method
Sedentary time (min/day)	day 1	Main outcome parameter of sedentary behaviour indication measured with ActivPAL3

Secondary Outcome Measures

Name	Time	Method
Lean mass (kg)	day 1	Parameter of body composition measured with DEXA-scan
Diastolic blood pressure	day 1	Parameter of cardiovascular health
Blood glucose concentration	day 1	Parameter of glucose homeostatis
Blood high density lipoprotein concentration	day 1	Parameter of lipid metabolism
Moderate-to-vigorous physical activity time (min/day)	day 1	Physical activity parameter measured with ActivPAL3
Blood triglyceride concentration	day 1	Parameter of lipid metabolism
Fat mass (kg)	day 1	Parameter of body composition measured with DEXA-scan
Blood low density lipoprotein concentration	day 1	Parameter of lipid metabolism
Light physical activity time (min/day)	day 1	Physical activity parameter measured with ActivPAL3
Blood insulin concentration	day1	Parameter of glucose homeostatis
Blood total cholesterol concentration	day 1	Parameter of lipid metabolism
Systolic blood pressure	day 1	Parameter of cardiovascular health
Maximal oxygen uptake	day 1	Parameter of oxygen capacity measured with cardiopulmonary exercise testing

Trial Locations

Locations (1)

Wouter Franssen; 🇧🇪 Diepenbeek, Limburg, Belgium