Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection

Not Applicable

Recruiting

• Conditions: Brain Metastases
• Interventions: Procedure: Microsurgical resection; Procedure: Gamma Knife radiosurgery

• Registration Number: NCT04857905
• Lead Sponsor: Medical University of Vienna

Brief Summary

Background. Brain metastases (BM) are the most common intracranial tumor and occur in 20-40% of all oncological patients. The most common primary cancer in brain metastases is lung cancer, followed by melanoma, breast cancer, renal cancer and colorectal cancer. The incidence of brain metastases has been increasing but the occurrence of brain metastases is still associated with high morbidity and poor prognosis. The main treatment methods are stereotactic radiosurgery (SRS), microsurgical resection and whole brain irradiation (WBRT). In contrast to microsurgical resection, Gamma Knife radiosurgery (GKRS) is a non-invasive neurosurgical method, which allows treatment in multimorbid patients with contraindications for surgery in general anesthesia. Furthermore, stereotactic radiosurgery is the only local treatment method for multiple disseminated and thereby non-resectable brain metastases. In general, microsurgical resection is considered the treatment of choice for BM exceeding \>3 cm in diameter. However, since the establishment of the dose-staged technique, larger metastases can also be treated radiosurgically in selected patients. This novel method allows the application of high cumulative dose for the treatment of complex brain metastases.

Aim. The aim of the study is to evaluate the clinical outcome in brain metastases patients with tumor volume between 8 and 20 ccm3. The clinical outcome will be compared between surgically and radiosurgically treated BM patients.

Patients and methods. The investigators plan to conduct an explorative prospective study including about 50 radiosurgically and 50 surgically treated patients with brain metastases. If a patient fulfill study-relevant inclusion criteria at the time of BM diagnosis, the principle study investigator will offer both treatment options to the patient. Depending on patient's choice, he/she will be categorized either to surgical or to radiosurgical treatment group. For the outcome evaluation of the different treatment options, a comprehensive database will be established. The study participations will not interfere with any clincally indicated therapeutic decisions and the study participants will not be exposed to any additional risks since both treatments represent suitable therapy options.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-01
• Study First Submitted: 2021-04-15
• Study First Submitted QC: 2021-04-20
• Study First Posted: 2021-04-23
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-04
• Last Update Posted: 2024-01-05
• Primary Completion: 2025-07-01
• Study Completion: 2025-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients over 18 years and under 90 years
• Patients with KPS ≥70
• Patients with NSCLC, melanoma, breast cancer or renal cancer as primary tumor
• Maximum of three brain metastases on the diagnostic MRI
• Tumor volume of 8-20 ccm3 on the diagnostic MRI
• Lobular brain metastases
• Patients without any contraindications for both treatment options
• Written, signed informed consent for study particaption after study explanation

Read More

Exclusion Criteria

• Patients under 18 years and over 90 years
• Patients with KPS <70
• Patients with other primary tumor
• More than three brain metastases on the diagnostic MRI
• Tumor volume <8 or >20 ccm3 on the diagnostic MRI
• Patients with contraindications for both treatment options

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Microsurgical Resection of larger Brain Metastasis	Microsurgical resection	Patients over 18 years and under 90 years Patients with KPS ≥70 Patients with NSCLC, melanoma, breast cancer or renal cancer as primary tumor Maximum of three brain metastases on the diagnostic MRI Tumor volume of 8-20 ccm3 on the diagnostic MRI Lobular brain metastases Patients without any contraindications for both treatment options Written, signed informed consent for study particaption after counseling -\> Patients who after counseling decide for microsurgical resection of their brain metastasis
Radiosurgery of larger Brain Metastasis	Gamma Knife radiosurgery	Patients over 18 years and under 90 years Patients with KPS ≥70 Patients with NSCLC, melanoma, breast cancer or renal cancer as primary tumor Maximum of three brain metastases on the diagnostic MRI Tumor volume of 8-20 ccm3 on the diagnostic MRI Lobular brain metastases Patients without any contraindications for both treatment options Written, signed informed consent for study particaption after study counseling -\> Patients who after counseling decide for dose-staged radiosurgical treatment of their brain metastasis

Primary Outcome Measures

Name	Time	Method
Overall survival	Through completion of the study, an average of 1 year	Time from first treatment

Secondary Outcome Measures

Name	Time	Method
Local tumor progression	Through completion of the study, an average of half a year	Time from first treatment until local tumor progression

Trial Locations

Locations (1)

Department of Neurosurgery, Medical University of Vienna; 🇦🇹 Vienna, Austria