Use of Antibiotic Prophylaxis on Urethral Catheter Withdrawal: A Randomized Double-Blind Placebo-Controlled Trial

St. Antonius Hospital1 site in 1 country100 target enrollmentJanuary 2005

ConditionsUrinary Tract Infection Bacteriuria

Drugstrimethoprim-sulfamethoxazole ciprofloxacin

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Urinary Tract Infection
Sponsor: St. Antonius Hospital
Enrollment: 100
Locations: 1
Primary Endpoint: Symptomatic bacteriuria
Status: Completed
Last Updated: 19 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The purpose of this study is to determine whether antibiotic prophylaxis for urinary catheter removal is useful at preventing catheter-associated urinary-tract infection.

Detailed Description

Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The researchers undertake a double-blind, placebo-controlled trial to assess the efficacy of single-dose therapy of trimethoprim-sulfamethoxazole or ciprofloxacin, versus placebo therapy in selected groups of surgical patients who had bladder drainage scheduled to last longer than 3 days.

Registry

clinicaltrials.gov

Start Date

January 2005

End Date

April 2007

Last Updated

19 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

St. Antonius Hospital

Eligibility Criteria

Inclusion Criteria

•Urethral catheter in situ for at least 3 days (72h)

Exclusion Criteria

•Pregnancy
•Impaired renal or hepatic function (serum creatinine \> 150 mmol/l, serum transaminases \> 75 IU/l)
•Symptomatic urinary tract infection
•Antibiotic use ≤ 48 hours before urinary catheter removal
•Allergy to trimethoprim-sulfamethoxazole or ciprofloxacin
•Urologic pathology