Circulating SIRT6 Expression, Effect on Aging Quality

Not Applicable

Completed

• Conditions: Aging

• Registration Number: NCT01567176
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-02
• Study Start: 2012-03
• Study First Submitted: 2012-03-08
• Study First Submitted QC: 2012-03-28
• Study First Posted: 2012-03-30
• Primary Completion: 2012-09
• Study Completion: 2012-09
• Last Update Submitted: 2019-05-23
• Last Update Posted: 2019-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Volunteers from the SUVIMAX 2 aging cohort
• Men and women
• Older than 60
• Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study
• Covered by Health Insurance System

Exclusion Criteria

• Subject not in compliance with the recommendation of French National Law

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Sirt6 expression in circulating leukocytes based on the aging quality	participants will be followed for the duration of the visit, an expected average of 1 day	analysis by quantitative RT-PCR method

Secondary Outcome Measures

Name	Time	Method
Physical examination and anthropometric measurement	participants will be followed for the duration of the visit, an expected average of 1 day	Measurement of the weight, height, waist, hips, blood pressure, pulse.
hand and forearm muscular strength measurement	participants will be followed for the duration of the visit, an expected average of 1 day	Hand Grip strength test
Physical Activity questionnaire	participants will be followed for the duration of the visit, an expected average of 1 day	MAQ (Modifiable Activity Questionnaire)
Cognitive assessment	participants will be followed for the duration of the visit, an expected average of 1 day	MMSE (Mini Mental State Examination), Five-word test, clock drawing

Trial Locations

Locations (2)

Centre de recherche en nutrition humaine Rhone-Alpes; 🇫🇷 Pierre Bénite, France

Centre de Recherche en Nutrition Humaine; 🇫🇷 Pierre Bénite, France