S0120, Studying Blood and Bone Marrow Samples From Patients With Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, or Plasmacytoma
- Conditions
- Plasma Cell MyelomaPrecancerous ConditionMultiple Myeloma
- Registration Number
- NCT00900263
- Lead Sponsor
- SWOG Cancer Research Network
- Brief Summary
RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients with monoclonal gammopathy of undetermined significance, multiple myeloma, or plasmacytoma may help doctors learn more about changes that occur in DNA and identify biomarkers related to these diseases. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is looking at blood and bone marrow samples from patients with monoclonal gammopathy of undetermined significance, multiple myeloma, or plasmacytoma.
- Detailed Description
OBJECTIVES:
* Establish a serum, cell, and bone marrow tissue bank of prospectively collected samples from patients with monoclonal gammopathy of undetermined significance (MGUS), asymptomatic multiple myeloma, solitary plasmacytoma, or other plasma cell dyscrasias.
* Evaluate the feasibility of accruing patients with these diseases.
* Determine whether patterns of gene expression or cytogenetics exist that allow molecular delineation of MGUS subtypes.
* Characterize cellular and humoral immune response to known tumor antigens in these patients.
* Cryopreserve serum/T cells for future evaluation.
* Preliminarily identify biological correlates that may relate to progression to symptomatic disease.
OUTLINE: Patients are stratified according to diagnosis (monoclonal gammopathy of undetermined significance \[MGUS\] or other plasma cell dyscrasias vs asymptomatic multiple myeloma vs solitary plasmacytoma).
Blood and bone marrow samples are collected and analyzed for microarray analysis, cytogenetic analysis, and immunobiology studies.
Unused samples may be stored for future research studies.
Patients are followed periodically for 5 years.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 375
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Disease progression 5 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (69)
Lahey Clinic Medical Center - Burlington
🇺🇸Burlington, Massachusetts, United States
Heartland Regional Medical Center
🇺🇸Saint Joseph, Missouri, United States
Saint Joseph Oncology, Incorporated
🇺🇸Saint Joseph, Missouri, United States
St. James Healthcare Cancer Care
🇺🇸Butte, Montana, United States
Big Sky Oncology
🇺🇸Great Falls, Montana, United States
Great Falls Clinic - Main Facility
🇺🇸Great Falls, Montana, United States
Sletten Cancer Institute at Benefis Healthcare
🇺🇸Great Falls, Montana, United States
Kalispell Medical Oncology at KRMC
🇺🇸Kalispell, Montana, United States
Kalispell Regional Medical Center
🇺🇸Kalispell, Montana, United States
Montana Cancer Specialists at Montana Cancer Center
🇺🇸Missoula, Montana, United States
McDowell Cancer Center at Akron General Medical Center
🇺🇸Akron, Ohio, United States
CCOP - Upstate Carolina
🇺🇸Spartanburg, South Carolina, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
🇺🇸Spartanburg, South Carolina, United States
Wenatchee Valley Medical Center
🇺🇸Wenatchee, Washington, United States
Cleveland Clinic Taussig Cancer Center
🇺🇸Cleveland, Ohio, United States
Harborview Medical Center
🇺🇸Seattle, Washington, United States
Minor and James Medical, PLLC
🇺🇸Seattle, Washington, United States
Fred Hutchinson Cancer Research Center
🇺🇸Seattle, Washington, United States
Group Health Central Hospital
🇺🇸Seattle, Washington, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
🇺🇸Seattle, Washington, United States
Polyclinic First Hill
🇺🇸Seattle, Washington, United States
University Cancer Center at University of Washington Medical Center
🇺🇸Seattle, Washington, United States
USC/Norris Comprehensive Cancer Center and Hospital
🇺🇸Los Angeles, California, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Heartland Hematology Oncology Associates, Incorporated
🇺🇸Kansas City, Missouri, United States
University of Mississippi Cancer Clinic
🇺🇸Jackson, Mississippi, United States
Veterans Affairs Medical Center - Hines
🇺🇸Hines, Illinois, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital
🇺🇸Kansas City, Missouri, United States
North Kansas City Hospital
🇺🇸Kansas City, Missouri, United States
CCOP - Kansas City
🇺🇸Kansas City, Missouri, United States
St. Vincent Healthcare Cancer Care Services
🇺🇸Billings, Montana, United States
Highlands Oncology Group - Springdale
🇺🇸Bentonville, Arkansas, United States
Tammy Walker Cancer Center at Salina Regional Health Center
🇺🇸Salina, Kansas, United States
Saint Louis University Cancer Center
🇺🇸Saint Louis, Missouri, United States
Bozeman Deaconess Cancer Center
🇺🇸Bozeman, Montana, United States
Saint Luke's Hospital - South
🇺🇸Overland Park, Kansas, United States
St. Joseph Medical Center
🇺🇸Kansas City, Missouri, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
🇺🇸Billings, Montana, United States
Liberty Hospital
🇺🇸Liberty, Missouri, United States
Evergreen Hematology and Oncology, PS
🇺🇸Spokane, Washington, United States
Cotton-O'Neil Cancer Center
🇺🇸Topeka, Kansas, United States
Tulane Cancer Center Office of Clinical Research
🇺🇸Alexandria, Louisiana, United States
Clemens Regional Medical Center
🇺🇸Mount Clemens, Michigan, United States
Northern Montana Hospital
🇺🇸Havre, Montana, United States
St. Peter's Hospital
🇺🇸Helena, Montana, United States
Rocky Mountain Oncology
🇺🇸Casper, Wyoming, United States
Shawnee Mission Medical Center
🇺🇸Shawnee Mission, Kansas, United States
Providence Cancer Center at Providence Hospital
🇺🇸Mobile, Alabama, United States
Parvin Radiation Oncology
🇺🇸Kansas City, Missouri, United States
CCOP - Montana Cancer Consortium
🇺🇸Billings, Montana, United States
Welch Cancer Center at Sheridan Memorial Hospital
🇺🇸Sheridan, Wyoming, United States
Wilford Hall Medical Center
🇺🇸Lackland AFB, Texas, United States
Menorah Medical Center
🇺🇸Overland Park, Kansas, United States
Glacier Oncology, PLLC
🇺🇸Kalispell, Montana, United States
Josephine Ford Cancer Center at Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Northern Rockies Radiation Oncology Center
🇺🇸Billings, Montana, United States
Good Samaritan Cancer Center at Good Samaritan Hospital
🇺🇸Kearney, Nebraska, United States
Wayne Memorial Hospital, Incorporated
🇺🇸Goldsboro, North Carolina, United States
Columbia Basin Hematology
🇺🇸Kennewick, Washington, United States
Harrison Poulsbo Hematology and Onocology
🇺🇸Poulsbo, Washington, United States
Brooke Army Medical Center
🇺🇸Fort Sam Houston, Texas, United States
Billings Clinic - Downtown
🇺🇸Billings, Montana, United States
Cancer Care Northwest - Spokane South
🇺🇸Spokane, Washington, United States
Saint Luke's East - Lee's Summit
🇺🇸Lee's Summit, Missouri, United States
St. Joseph Cancer Center
🇺🇸Bellingham, Washington, United States
Olympic Hematology and Oncology
🇺🇸Bremerton, Washington, United States
Skagit Valley Hospital Cancer Care Center
🇺🇸Mt. Vernon, Washington, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
🇺🇸Missoula, Montana, United States
Research Medical Center
🇺🇸Kansas City, Missouri, United States