The Effects of Programmed Death-ligand 1 on Postoperative Pain for Lung Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the incidence of chronic pain after surgery
研究概览
简要总结
The concentration of plasma programmed death-ligand 1(PD-L1) for lung cancer patients before video-assisted thoracoscopic surgery is detected. According to the distribution of plasma concentration, patients are divided into high or low expression of PD-L1. Differences in acute and chronic postoperative pain are compared between two groups of patients. And effects of PD-L1 expresion on postoperative pain in lung cancer patients are explained.
详细描述
Chronic pain after video-assisted thoracoscopic surgery (VATS) has been a major concern for lung cancer patients. The relationship between plasma programmed cell death ligand-1 (PD-L1) concentration and chronic pain in post-VATS is uncertain. This study aims to explore the effects of PD-L1 levels on chronic pain and provide proactive pain management regimen according to individual genetic differences.
The concentration of plasma PD-L1 for lung cancer patients before video-assisted thoracoscopic surgery is detected. According to the distribution of plasma concentration, patients are divided into high or low expression of PD-L1. Differences in acute and chronic postoperative pain are compared between two groups of patients. And effects of PD-L1 expresion on postoperative pain in lung cancer patients are explained.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status I-IV (males and females).
- •18-80 years of age.
- •Patients undergoing video-assisted thoracoscopic surgery for malignant lung disease.
排除标准
- •History of opioid abuse.
- •Known psychiatric disorders.
- •Unexpected conversion to thoracotomy or transferred to intensive care unit for further treatment.
- •Combined with other surgeries or sites.
结局指标
主要结局
the incidence of chronic pain after surgery
时间窗: 3 months after surgery
Patients were followed up by the Brief Pain Inventory questionnaire about the details of chronic pain.
次要结局
未报告次要终点
研究者
Yi Feng, MD
director of department of Anesthesiology and Pain medicine
Peking University People's Hospital