Efficacy of jayanti ashwagandha vatti as adjuvent therapy with antikochs treatment in pulmonary tuberculosis

The largest number of cases occurs in the Southeast Asia region which accounts for about a third of the global prevalence and populated nations like China and India are on alarming bomb. Moreover, India is the highest TB burden country accounting for more than one fifth of the global incidence.To prevent acquired resistance and a successful treatment; it is recommended to receive a combination chemotherapy containing the main drugs Isoniazid -H (INH), Rifampicin-R (RMP) and Pyrazinamide-Z (PZA), ethambutol (EMB)and/or Streptomycin. These drugs are used in combination for initial 2 month followed by a continues use of INH + RMP for 4-6 month as a complete treatment regimen for active tuberculosis. To reduce the incidence of hepatotoxicity in TB patients, various measures have been taken with revised recommendations for drugs and patient selection criteria. But until today no drug has been developed in conventional health science for prevention of hepatotoxicity. The only measure available for managing ATT induced hepatotoxicity is withdrawal of the therapeutic drugs when observed an evidence of liver damage and reintroducing the same after normalization of liver enzymes. It has been observed that most of the patients suffering from Tuberculosis find difficulty to complete the recommended treatment regimen due to hepatotoxicity caused due to the ATT drugs. Thus, some adjuvant therapy is essential which could reduce the hepatotoxicity of the therapeutic drugs. Therefore, keeping these facts in mind this study has been planned to provide better, safer and faster relief to thepatients suffering from Tuberculosis and for this I have choose use of Rasayana therapy purpose a compound formulation of Jayanti vati along with Ashwagandha has been prepared. Both of these drugs have well established hepato protective, immuno-modulatory action and are frequently used by Acharyas for the treatment of tuberculosis due to their Rasayana properties.