Pilot Study: Topical Antibiotics for Prevention of ICU Central Line Infections
Overview
- Phase
- Not Applicable
- Intervention
- Polysporin Triple Therapy ointment
- Conditions
- Blood Stream Infections
- Sponsor
- Fraser Health
- Locations
- 1
- Primary Endpoint
- Overall number of line related infections (local and blood borne)
- Status
- Withdrawn
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of the study is to determine if the overall central venous catheter related infection rate can be reduced by the application of Polysporin Triple Therapy ointment to the insertion site.
Detailed Description
Previous studies in the dialysis population have found a reduction in local and system central venous catheter related infections with the application of topical antibiotics to the insertion point. One such study found a mortality benefit with Polysporin Triple Therapy ointment. We intend to determine if this preparation can reduce overall line infection rates in the ICU environment through its application at the time of line insertion and twice more the following week.
Investigators
Steve Reynolds
Critical care Physician
Fraser Health
Eligibility Criteria
Inclusion Criteria
- •all patients admitted to the ICU requiring a central venous catheter
Exclusion Criteria
- •previous line infection during same ICU stay
- •CVC for hemodialysis
Arms & Interventions
Polysporin Triple Therapy
Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week.
Intervention: Polysporin Triple Therapy ointment
Placebo
Petroleum jelly
Intervention: Petroleum Jelly
Outcomes
Primary Outcomes
Overall number of line related infections (local and blood borne)
Time Frame: 6 months
Secondary Outcomes
- Length of hospital stay(7 months)
- Prevalence of methicillin-resistant Staphylococcus Aureus (MRSA)(12 months)
- Length of ICU stay(7 months)