Pilot Study: Topical Antibiotics for Prevention of ICU Central Line Infections
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Overall number of line related infections (local and blood borne)
研究概览
简要总结
The purpose of the study is to determine if the overall central venous catheter related infection rate can be reduced by the application of Polysporin Triple Therapy ointment to the insertion site.
详细描述
Previous studies in the dialysis population have found a reduction in local and system central venous catheter related infections with the application of topical antibiotics to the insertion point. One such study found a mortality benefit with Polysporin Triple Therapy ointment. We intend to determine if this preparation can reduce overall line infection rates in the ICU environment through its application at the time of line insertion and twice more the following week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients admitted to the ICU requiring a central venous catheter
排除标准
- •previous line infection during same ICU stay
- •CVC for hemodialysis
研究组 & 干预措施
Polysporin Triple Therapy
Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week.
干预措施: Polysporin Triple Therapy ointment (Drug)
Placebo
Petroleum jelly
干预措施: Petroleum Jelly (Other)
结局指标
主要结局
Overall number of line related infections (local and blood borne)
时间窗: 6 months
次要结局
- Length of hospital stay(7 months)
- Prevalence of methicillin-resistant Staphylococcus Aureus (MRSA)(12 months)
- Length of ICU stay(7 months)
研究者
Steve Reynolds
Critical care Physician
Fraser Health