Effects of continuous positive airway pressure on cardiac autonomic control, airway inflammation and oxidative stress in Thai patients with obstructive sleep apnea
- Conditions
- Obstructive sleep apneaAirway inflammation
- Registration Number
- TCTR20160413001
- Lead Sponsor
- Faculty of Medicine, Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 15
Twenty-four patients whose age was between 30 to 70 years old volunteered to participate in the study. Patients were treated with CPAP while sleeping at night for at least five hours per night for at least five days per week for three consecutive months. Patients were diagnosed with OSA by medical specialists using polysomnography (PSG) within the month preceding the start of the study. Patients included in this study had an arousal index (AI) of at least 15/h and no history of cardiovascular disease (e.g. coronary heart disease and myocardial infarction).
Patients with a history of autoimmune conditions or symptoms of respiratory tract infection in the six weeks prior to the study, history of sleep apnea treatment with CPAP or oral devices, tracheostomy, or use of oxygen therapy at home were excluded. Study subjects with history of other diseases associated with high FeNO (e.g. viral respiratory tract infections, systemic lupus erythematosis, liver cirrhosis, acute lung allograft rejection, and post-transplant bronchiolitis obliterans) or history of other diseases associated with low FeNO (i.e. cystic fibrosis, HIV infection and pulmonary hypertension) were excluded as well.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method airway inflammation 06/10/2014 to 26/10/2015 FeNO
- Secondary Outcome Measures
Name Time Method Oxidative stress 06/10/2014 to 26/10/2015 MDA