TCTR20160413001
Completed
未知
Effect of continuous positive airway pressure on airway inflammation and oxidative stress in patients with obstructive sleep apnea
Faculty of Medicine, Khon Kaen University0 sites15 target enrollmentApril 13, 2016
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Obstructive sleep apnea
- Sponsor
- Faculty of Medicine, Khon Kaen University
- Enrollment
- 15
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Twenty\-four patients whose age was between 30 to 70 years old volunteered to participate in the study. Patients were treated with CPAP while sleeping at night for at least five hours per night for at least five days per week for three consecutive months. Patients were diagnosed with OSA by medical specialists using polysomnography (PSG) within the month preceding the start of the study. Patients included in this study had an arousal index (AI) of at least 15/h and no history of cardiovascular disease (e.g. coronary heart disease and myocardial infarction).
Exclusion Criteria
- •Patients with a history of autoimmune conditions or symptoms of respiratory tract infection in the six weeks prior to the study, history of sleep apnea treatment with CPAP or oral devices, tracheostomy, or use of oxygen therapy at home were excluded. Study subjects with history of other diseases associated with high FeNO (e.g. viral respiratory tract infections, systemic lupus erythematosis, liver cirrhosis, acute lung allograft rejection, and post\-transplant bronchiolitis obliterans) or history of other diseases associated with low FeNO (i.e. cystic fibrosis, HIV infection and pulmonary hypertension) were excluded as well.
Outcomes
Primary Outcomes
Not specified
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