Gene expression and immunohistochemistry analysis of soft tissue covering bone grafted with xenograft in huma
- Conditions
- Patients with edentulism who must or mustn't have bone grafting using xenograft for dental implant treatmentXenograft
- Registration Number
- TCTR20240620002
- Lead Sponsor
- Office of Research Affairs, Faculty of Dentistry, Chulalongkorn University
- Brief Summary
The result shows that the relative gene expression of TNF-a, IL-6, IL-8, and NF-kB1 are not significantly different in soft tissue covering xenograft compared to the ones in soft tissue covering normal bone healing.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 16
1.In the bone grafting group, subjects must have bone grafting using xenograft.
2.All of subjects must have implant placements using The Straumann Dental Implant, Basel, Switzerland.
3.A period of at least 3 months between extraction and implant placement.
4.All of subjects must have enough excess soft tissue after implant placement that can be collected without interfering the normal treatment protocol.
1.The risk factors that affect soft tissue inflammation including uncontrolled diabetes, uncontrolled periodontal disease, previously peri-implantitis, or smoking.
2.Use of antibiotics, anti-inflammatory drugs, or local antimicrobial agents within the former 6 months.
3.Subjects that do not have enough excess soft tissue after implant placement which the collecting process will interfere the normal treatment protocol.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gene expression After 4-6 months of bone grafting Relative gene expression level
- Secondary Outcome Measures
Name Time Method Immunohistochemistry After 4-6 months of bone grafting Immunohistochemistry