JPRN-UMIN000006526已完成未知
Antihypertensive Treatment in Acute Cerebral Hemorrhage-II - ATACH-II
niversity of Minnesota National Cerebral and Cardiovascular Center0 个研究点目标入组 1,000 人开始时间: 2011年10月14日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 1,000
研究概览
简要总结
We conducted a multicenter trial where eligible subjects with ICH were randomized to intensive (<140 mm Hg) and standard (<180 mm Hg) SBP reduction in a 1:1 ratio <4.5h. The primary outcome of death and disability was ascertained at 3-M post randomization. Compared with standard SBP reduction, intensive SBP reduction in patients with ICH did not lower the rate of death and disability despite achieving a small magnitude reduction in hematoma expansion.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1.ICH is due to previously known neoplasms, AVM, or aneurysms 2.Intracerebral hematoma considered to be related to trauma 3.ICH located in infratentorial regions such as pons or cerebellum 4.IVH associated with intraparenchymal hemorrhage and blood completely fills one lateral ventricle or more than half of both ventricles 5.Patient to receive immediate surgical evacuation 6.Current pregnancy, parturition within previous 30 days or active lactation 7.Use of warfarin within the last 5 days and INR >4 8.A platelet count less than 50,000/mm3 9.Known sensitivity to nicardipine 10.Pre-morbid disability requiring assistance in ambulation or activities of daily living 11.Subjects living will precludes aggressive ICU management 12.Subject is currently participating in another interventional clinical trial
研究者
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