Study of combined neoadjuvant chemotherapy and letrozol in Postmenopausal Women with locally advanced breast cancer

Completed

• Conditions: Breast cancer; Cancer - Breast

• Registration Number: ACTRN12608000523303
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-10-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1. Postmenopausal women with pathologically proven locally advanced breast cancer
2. No prior therapy
3. No clinical or imaging evidence of distant metastasis at the time of study enrollment
4. Karnofsky performance status = 70
5. Written informed consent
6. Normal or acceptable liver, kidney and bone marrow function

Exclusion Criteria

1. Prior therapy
2. Clinical or imaging evidence of distant metastasis
3. Patients with a known contraindication or allergy to aromatase inhibitors
4. Patients with severe heart, cardiovascular, liver, renal, inflammatory intestinal or blood coagulation disorders,

Study & Design

• Study Type: Interventional
• Study Design: Not specified