Use of Diuretics in Maintenance Hemodialysis Patients Undergoing Bioimpedance-guided Fluid Management

Not Applicable

• Conditions: Diuretic Abuse
• Interventions: Drug: Furosemid hydrochlorothiazide

• Registration Number: NCT04182854
• Lead Sponsor: Capital Medical University

Brief Summary

Background.The objective of the present study is to verify whether using diuretics will improve either blood pressure or fluid overload in maintenance hemodialysis patients with residual diuresis kidney function.

Detailed Description

Methods.46 maintenance hemodialysis patients will be given three stages of diuretic intervention: 100mg furosemide every day for 1 month, 200mg furosemide every day for 1 month, and 100mg furosemide combined with 25mg hydrochlorothiazide every day for 1 month. The 24-hour urine volume, 24-hour urine sodium, 24-hour urine potassium, blood pressure, OH(overhydration) and dry weight will be collected. OH will be measured by bioelectrical impedance.

Study Timeline

• Study Start: 2019-10-28
• Study First Submitted: 2019-11-22
• Study First Submitted QC: 2019-11-29
• Study First Posted: 2019-12-02
• Primary Completion: 2020-02-01
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-31
• Last Update Posted: 2021-06-02
• Study Completion: 2021-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• maintenance hemodialysis patient
• unrine volume more than 100ml.

Exclusion Criteria

• myocardial infarction;
• unrine volume less than 100ml.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
diuretics	Furosemid hydrochlorothiazide	-

Primary Outcome Measures

Name	Time	Method
urine volume increasing after diuretic use in maintenance hemodialysis patients with residual renal function	up to 16 months

Trial Locations

Locations (1)

Peking University internation Hospital; 🇨🇳 Beijing, Beijing, China