Feasibility of Neostigmine as a Reversal Agent of Neuromuscular Blockade for Intraoperative Neuromonitoring During Thyroid Surgery: a Prospective Randomized Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Neostigmine
- Conditions
- Thyroid Diseases
- Sponsor
- Seoul National University Hospital
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Time to recovery of cricothyroid muscle twitching
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
For successful intraoperative neuromonitoring (IONM), adequate reversal of neuromuscular blocking agent is a prerequisite in thyroid surgery with .
The aim of this study is to investigate the feasibility of neostigmine just after tracheal intubation on the IONM in thyroid surgery.
Detailed Description
For successful intraoperative neuromonitoring (IONM), adequate reversal of neuromuscular blocking agent is a prerequisite in thyroid surgery with . The aim of this study is to investigate the feasibility of neostigmine just after tracheal intubation on the IONM in thyroid surgery. This study will be performed as a randomized controlled trial with two groups (N group: neostigmine group and NS group: normal saline group). For the N group, neostigmine (0.03 mcg / kg) and glycopyrrolate with a 5:1 ratio will be administered just after tracheal intubation. For the NS group, normal saline with a same volume of the N group will be administered just after tracheal intubation. For all patients of two groups, investigators evaluate the quality of signal of IONM during the surgery.
Investigators
Jung-Man Lee
Associate professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •open thyroid surgery with intraoperative neuromonitoring
Exclusion Criteria
- •refusal to participate in the study
- •rocuronium should not be used (e.g. renal dysfunction patient)
Arms & Interventions
Neostigmine
For the Neostigmine (N) group, neostigmine (0.03 mcg / kg) and glycopyrrolate with a 5:1 ratio will be administered just after tracheal intubation. Investigators evaluate the quality of signal of IONM during the surgery.
Intervention: Neostigmine
Normal saline
For the Normal saline (NS) group, normal saline with a same volume of the N group will be administered just after tracheal intubation. Investigators evaluate the quality of signal of IONM during the surgery.
Intervention: Normal saline
Outcomes
Primary Outcomes
Time to recovery of cricothyroid muscle twitching
Time Frame: perioperative
Time from the rocuronium administration to recovery of cricothyroid muscle twitching
Secondary Outcomes
- amplitude of EMG for V2(During surgery)
- amplitude of EMG for R1(During surgery)
- amplitude of EMG for V1(During surgery)
- amplitude of EMG for R2(During surgery)
- number of patients with involuntary movements disrupting surgery(During surgery)