PACTR201510001274643招募中未知
Clinical effect of lowering heart rate in sepsis syndromes; comparing ivabradine 10 mg and 15 mg versus placebo.
anesthesia and ICU departement , faculty of medicine, Cairo univ0 个研究点目标入组 90 人开始时间: 2015年9月20日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Year(s) 至 99 Year(s)（—）
- 性别
- All
入选标准
- •severe sepsis, septic shock or Multiple organ dysfunction syndrome
- •-Sinus rhythm with heart rate ¿ 90bpm
排除标准
- •refusal by the patient or the responsible guardian
- •¿Patients younger than 18 years of age
- •¿Hypersensitivity to the active substance or any of the excipients
- •¿Pregnancy, lactation
- •¿Patients with a history of pre-existing chronic renal failure with a glomerular filtration rate <30ml/min
- •¿Patients with malignant hyperthermia or burn patients
- •¿Patients with acute rejection after organ transplantation
- •¿Patients who have participated or participate in other studies within the last 3 months
- •¿Other types of shock than septic or cardiogenic shock
- •¿Patients with severe valvular heart disease
- •¿Severe hepatic insufficiency
- •¿Sick sinus syndrome
- •¿pacemaker-dependency
- •¿3rd degree AV block
- •¿Use of potent cytochrome P450 3A4 inhibitors such as antifungals of the azole -type (ketoconazole, itraconazole), macrolide antibiotics (clarithromycin, erythromycin)
研究者
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