The Spread of Aerosols During Respiratory Manoeuvres and During Administration of Respiratory Support in Patients with Respiratory Disease and Healthy Volunteers

Woolcock Institute of Medical Research0 个研究点目标入组 42 人开始时间: 2021年9月13日最近更新: 2021年9月20日

试验速览

暂无简介。

•Healthy Participants
•Subjects recruited will have normal lung function with no underlying physician-diagnosed respiratory disease and satisfy the following criteria:
•Non-smoker with pack years < 10 years
•BMI < 30kg/m3
•Respiratory Disease Patients
•Subjects recruited will be admitted to RNSH with resolved infective pulmonary pathology, or attending outpatient clinics with physician-diagnosed respiratory disease

•Healthy Participants
•No Intensive Care Unit admissions in the last 12 months.
•Active or chronic respiratory pathologies (for example, interstitial lung disease, asthma, chest wall pathology causing ventilatory restriction)
•History of lung surgery (including lobectomy or pneumonectomy, but not lung biopsy) or thoracic radiation therapy (excluding isolated mediastinal radiation therapy with no evidence of subsequent pulmonary fibrosis)
•Any major comorbidities deemed to impact on respiratory physiology or symptoms, including severe on uncontrolled heart failure, morbid obesity (BMI >40), muscular or neurological disorders causing respiratory muscle weakness or dysfunctional swallowing
•History of chronic kidney disease (creatine greater than the upper limit of normal)
•Unable to perform lung function testing
•Women who are breast feeding, pregnant, or unwilling to avoid pregnancy during the study period
•Unable to provide informed consent
•Respiratory Disease Patients
•Unable to perform lung function testing
•Serious comorbidities that put the patient at risk when performing spirometry or during the administration of breathing support
•Unable to provide informed consent
•Known infective Tuberculosis, viral respiratory infection, or HIV.

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