Osteoradionecrosis and PENTOCLO Protocol: Retrospective Study

Completed

• Conditions: Osteoradionecrosis of Jaw

• Registration Number: NCT04097847
• Lead Sponsor: University Hospital, Brest

Brief Summary

osteoradionecrosis (ORN) affects up to 30% of irradiated patients and can occur up to several decades after stopping treatment. Differents therapeutics exist but there is no consensus concerning the management of the maxillary ORN. The understanding of new pathological mechanisms opens the way to new therapeutic perspectives.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-02
• Status Verified: 2019-02
• Primary Completion: 2019-04-01
• Study Completion: 2019-04-01
• Study First Submitted: 2019-05-14
• Study First Submitted QC: 2019-09-19
• Study First Posted: 2019-09-20
• Last Update Submitted: 2019-10-31
• Last Update Posted: 2019-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• Patient over 18 being or having been treated by pentoclo combination for an osteoradionecrosis of the jaw

Exclusion Criteria

• Tumoral recidivism
• Precocious stop of pentoclo

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical evolution of the osteoradionecrosis lesion after introducing PENTOCLO protocol	2 years	Retrospective study based on recovering patient data from medical records

Trial Locations

Locations (1)

CHRU de Brest; 🇫🇷 Brest, France