Brain and Genetic Predictors of Individual Differences in Pain and Analgesia

Completed

• Conditions: Pain, Acute

• Registration Number: NCT03781570
• Lead Sponsor: Trustees of Dartmouth College

Brief Summary

The purpose of the study is to gain a better understanding of pain processing in the brain. Our understanding of how pain is processed in the brain is limited. We are testing for individual differences in pain perception and emotion.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-07
• Study First Submitted: 2018-12-14
• Study First Submitted QC: 2018-12-17
• Study First Posted: 2018-12-20
• Primary Completion: 2023-10-01
• Study Completion: 2023-10-01
• Results First Submitted: 2024-04-09
• Status Verified: 2025-05
• Results First Submitted QC: 2025-05-19
• Last Update Submitted: 2025-05-19
• Results First Posted: 2025-05-21
• Last Update Posted: 2025-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 541

Inclusion Criteria

• Participants must be registered in the Colorado Community Twin Sample (CTS).

Exclusion Criteria

• Not being registered in the Colorado Community Twin Sample (CTS).
• Any MRI contraindications.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain Rating Scores Made on a Visual Analog Scale (VAS)	Measured during pain tasks at a single 4 hour experimental session (within one month of screening completion).	Self reported pain using a VAS ranging from 0-100 (with 0 representing "no pain at all" and 100 representing "most intense pain imaginable (in the context of the experiment)). Higher scores indicate more pain.

Trial Locations

Locations (1)

University of Colorado, Boulder; 🇺🇸 Boulder, Colorado, United States