Measurement of Exhaled Propofol During a Total Intravenous Anesthesia With Propofol and Remifentanil
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- exhaled propofol levels in breathing gas
研究概览
简要总结
Propofol is a common intravenous anaesthetic drug used for anaesthesia induction and for permanent infusion to maintain anaesthesia (total intravenous anaesthesia). Different to the volatile anaesthetics (feedback concentrations in exhaled breathing gas) piloting of an total intravenous anaesthesia with propofol is done only by experience of the anaesthetist or according to pharmacokinetic models. In this study we want to investigate if the exhaled fraction of propofol is a potential measurement parameter for piloting anaesthesia. Exhaled propofol will be measured with an electrochemical sensor developed by "Drägerwerk AG & Co. KGaA". Exhaled propofol levels will be compared with the corresponding arterial serum concentrations of propofol. Furthermore we investigate the correlation of exhaled propofol levels with the Bispectral Index (BIS).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA (American Society of Anaesthesiologists) classification I & II
- •Body-Mass-Index < 35
- •elective surgery with the necessity of an arterial catheter
排除标准
- •chronic obstructive lung disease
- •bronchial asthma
- •smokers with more than 5 packyears
- •peripheral artery occlusive disease
- •diabetes mellitus
结局指标
主要结局
exhaled propofol levels in breathing gas
时间窗: continous recording during the whole anaesthesia (duration depents on surgery, between 2 and 12 hours)
次要结局
- Bispectral Index (BIS)(continous recording during the whole anaesthesia (duration depents on surgery, between 2 and 12 hours))
- propofol concentration in arterial blood serum(samples taken during anaesthesia (13 blood samples), duration of anaesthesia depends on surgery, 2 to 12 hours)
研究者
Tino Münster
Prof. Dr.
University of Erlangen-Nürnberg Medical School