Normal Saline Versus Plasmalyte in Initial Resuscitation of Trauma Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Wounds and Injuries
- Sponsor
- University of California, Davis
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- Change in the base deficit
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to determine whether an intravenous salt solution called "Plasmalyte" causes less abnormality of the body's acid levels than a solution called "Normal Saline."
Detailed Description
Electrolyte-containing intravenous fluids are routinely administered to patients in the first few hours after acute traumatic injury. Although Normal Saline (0.9% sodium chloride) is commonly used in this setting, it causes a hyperchloremic acidosis that may exacerbate metabolic derangements that occur after acute injury. Plasmalyte A is a solution that more closely matches physiologic electrolyte levels. In this study, we will evaluate whether Plasmalyte A results in less disturbance of the base deficit 24 hours following traumatic injury than does Normal Saline.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Triaged upon arrival to the hospital as severely injured
- •At least 18 years of age
- •Meets at least one of the following criteria:
- •Intubated or likely to become intubated within 60 minutes of arrival at the hospital
- •Likely to need an operation within 60 minutes of arrival
- •Received or likely to receive a blood transfusion within 60 minutes of arrival
Exclusion Criteria
- •Greater than 60 minutes since arrival at the hospital
- •Death likely within 48 hours
- •Transfer from another hospital
- •Pre-existing renal failure requiring dialysis
- •Pregnancy
- •Prisoner status
Outcomes
Primary Outcomes
Change in the base deficit
Time Frame: 24 hours after randomization
Base deficit at 24 hours after randomization minus the base deficit at randomization
Secondary Outcomes
- Mortality(Hospital discharge)