Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
- Conditions
- HypertensionPrimary Aldosteronism
- Registration Number
- NCT06569589
- Lead Sponsor
- Jens Titze
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> 1. Age 21-70 years, with arterial hypertension or suspected to have primary<br> aldosteronism based on Endocrine Society Guidelines.<br><br> 2. Male and female patients older than 21 years.<br><br> 3. Willingness to participate and ability to provide informed consent.<br><br>Exclusion Criteria:<br><br> 1. Patients with exclusion criteria for the MRI, such as:<br><br> - implanted devices (surgical clips, heart pacemakers or defibrillators, cochlear<br> implants)<br><br> - iron-based tattoos<br><br> - any other pieces of metal or devices that are not MR-Safe anywhere in the body<br><br> - patients who exhibit noticeable anxiety and/or claustrophobia into the MRI<br> scanner<br><br> - pregnancy<br><br> 2. Diagnosis of heart failure NYHA classes III and IV<br><br> 3. Impaired renal function with eGFR<30 ml/min or proteinuria > 1 g/24h<br><br> 4. Liver disease with cirrhosis (Child-Pugh class C) or hypoalbuminemia<br><br> 5. Muscular dystrophies<br><br> 6. Patients with active cancer or severe comorbid conditions likely to compromise<br> survival or study participation<br><br> 7. Unwillingness or other inability to cooperate
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Patients with primary aldosteronism have a 10-20% higher muscle Na+ content compared to healthy controls
- Secondary Outcome Measures
Name Time Method High K+ intake reduces muscle Na+ in patients with primary aldosteronism;MR blockade reduces muscle Na+ conten in patients with primary aldosteronism;Compared to MR blockade, adenoma surgical removal is more efficient in reducing muscle Na+ in patients with primary aldosteronism