A randomised study to compare the neuroendocrine and stress response markers in patients undergoing laparoscopic cholecystectomy under conventional general anaesthesia versus under opioid free anaesthesia
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/08/056206
- Lead Sponsor
- niversity College of Medical Sciences and Guru Tegh Bahadur Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients giving consent for the study and belonging to ASA grade I or II,
scheduled for elective laparoscopic cholecystectomy under general anaesthesia.
Exclusion Criteria
1. Patients with known cardiovascular, pulmonary, psychological or neurological diseases
2. Patients who have signs and symptoms of raised intracranial tension
3. Patients with known allergies to the study drugs
4. Obese patients (BMI > 30kg/m2)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of CRP values at 24 hours post induction in the two groupsTimepoint: 24 hours post induction
- Secondary Outcome Measures
Name Time Method To compare in the two groups: <br/ ><br>Values at 6hrs post induction of various biochemical markers such as <br/ ><br>i) CRP ii) IL-6 iii) ESR iv) S. Cortisol v) S. Albumin vi) Blood Glucose <br/ ><br>Post-operative recovery using Modified Aldrete score <br/ ><br>Post-operative pain using Numeric Rating Scale (NRS) <br/ ><br>Total dose of rescue analgesia required in 24 hoursTimepoint: 6 & 24 hours post induction