Effect of intracameral Bevacizumab injection on corneal endothelial cells: an in vivo evaluatio

Not Applicable

Completed

• Conditions: Corneal endothelial toxicity; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12609000716268
• Lead Sponsor: Cairo University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-08-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

patients with iris neovascularization

Exclusion Criteria

corneal edema or preoperative corneal endothelial desnity<1500 cells/mm2

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
endothelial cell density.The Noncon Robo Pachy Model SP-9000LC specular microscope (Konan Medical Corporation, Miyanishi-cho, Nishinomiya, Hyogo, Japan) was used to record the central corneal endothelial image and measures the corneal thickness. A KSS-300 Image Storage System (Konan Medical Corporation, Miyanishi-cho, Nishinomiya, Hyogo, Japan) was used to capture and save the image from the Noncon Robo specular microscope. The KSS-300 Image Storage System was later used to analyze the corneal endothelial image, using the centre method after counting a minimum of 10 cells in each eye.[4 weeks post treatment]

Secondary Outcome Measures

Name	Time	Method
endothelial cell morphology.The Noncon Robo Pachy Model SP-9000LC specular microscope (Konan Medical Corporation, Miyanishi-cho, Nishinomiya, Hyogo, Japan) was used to record the central corneal endothelial image and measures the corneal thickness. A KSS-300 Image Storage System (Konan Medical Corporation, Miyanishi-cho, Nishinomiya, Hyogo, Japan) was used to capture and save the image from the Noncon Robo specular microscope. The KSS-300 Image Storage System was later used to analyze the corneal endothelial image, using the centre method after counting a minimum of 10 cells in each eye.[4 weeks post treatment];regression of iris neovascularization will be assessed by performing anterior segment flourescein angiography before injection and 4 weeks after the injection and comparing them[4 weeks post treatment]